Site: Breast

Inclusion Criteria:

• Intervention Arm Females
• No Rare Cancers
• No Prior History of Any Cancer
• T0 DNA Extracted from 2009-00553 or T0 Source Available
• Pre-Exit T0 DNA Extracted from 2009-00553 or T0 Source Available
• T0 Material is 4-7 Years Pre-Dx (Cases)
• Source Material Available in T3/T4/T5
• Pre-Exit Source Material Available in T3/T4/T5
• T3-T5 Material is 1-3 Years Pre-Dx (Cases)

Matching Factors:

• Age at Randomization (5 year intervals)
• Study Year of Blood Draw
• Calendar Year of Blood Draw
• Material Type

Match Ratio: 1:1

Match Technique: Frequency matching only non-cases as controls.

Additional Matching Comments: Matching factors pertaining to blood draw apply to both time points.

Analytes:

• C6orf79 percent methylated
• ERCC1 percent methylated
• MGAT4C percent methylated
• OPTN percent methylated
• PRKCDBP percent methylated
• methylated C6orf79
• methylated ERCC1
• methylated MGAT4C
• methylated OPTN
• methylated PRKCDBP
• unmethylated C6orf79
• unmethylated ERCC1
• unmethylated MGAT4C
• unmethylated OPTN
• unmethylated PRKCDBP

Number of Cases: 300

Number of Controls: 300

---