Benign Ovarian Pathology
Ovarian cancer screening with transvaginal ultrasound (TVU) and CA-125 in the PLCO trial produced a large number of false-positive tests, often resulting in surgical follow-up. Pathology reports from a selection of these surgical procedures were collected and reviewed to investigate findings that were not collected in the PLCO protocol.
Women with a false positive ovarian screen in any of the first four rounds of screening (T0-T3) with surgical follow-up were selected for review. For this collection, a screen was considered false positive if the woman had a positive TVU or positive CA-125 but was never diagnosed with ovarian cancer. Among the approximately 1,100 women with a false positive screen, 581 were selected for review based on screening results. All women with a positive CA-125, with or without a positive TVU, were selected. Of the over 900 women with a false positive TVU only, 400 were selected at random.
The selected pathology reports from surgeries following false-positive screens were reviewed by NCI pathologists. Findings were recorded onto a form designed by NCI investigators and data from the form was entered into a database.
Benign Ovarian Pathology data can be obtained in the Benign Ovarian Pathology dataset.
Pathologic findings following false-positive screening tests for ovarian cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial.
Nyante SJ, Black A, Kreimer AR, Duggan MA, Carreon JD, Kessel B, Buys SS, Ragard LR, Johnson KA, Dunn BK, Lamerato L, Commins JM, Berg CD, Sherman ME
Gynecol. Oncol. 2011 Mar; Volume 120 (Issue 3): Pages 474-9 PUBMED