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Digital images are available for most of the lung screen chest x-rays and some of the pathology collected for lung, colorectal and ovarian cancers. All requests for images are fulfilled via requestor provided hard drive. The requestor must bear the expense of the hard drive and all related shipping expenses, including prepaid return shipping. Signature requirement and acknowledgement of physical possession are required in a timely manner. Contact us if you have any questions.

Digitized Screening Chest X-ray Images

Chest x-rays were used to screen for lung cancer in the PLCO Trial. Of the 237,000 x-rays taken, approximately 205,000 are available in TIF format with a low-contrast compression technique (images may appear black to the naked eye). Nearly 58,000 participants who completed at least one screen have a digitized chest x-ray image available. NCI currently limits image requests to a subset of 25,000 participants (~88,000 images totaling 860GB).

A standardized selection of 25,000 participants, optimized to meet the requirements of most analyses, is available to streamline the selection process. The selection of participants can be customized when the standard selection is not adequate to meet the project requirements. This standard selection includes:

  • All participants with a T0-T5 lung cancer (n=595)
  • All participants with any abnormal/suspicious screens (n=10,646)
  • Randomly selected participants with any abnormal/not suspicious screens (n=7,580)
  • Randomly selected participants with all negative screens (n=6,179)

Digital Pathology Images

PLCO pathology images come from select ovarian, colorectal and lung cancer patients. They are images of H&E stained slides that were obtained as part of a pathology specimen collection to construct tissue microarrays (TMAs). The 2,071 H&E slides (and corresponding images) each came from blocks of tissue resected during diagnosis and treatment of cancer and preserved by pathology labs. Slides were digitized into SVS format. Ovarian and colorectal images have regions of interest circled in the image while lung images have no annotation.

Cancer # participants # images Size (est.)
Ovarian 73 225 247GB
Colorectal 77 332 332GB
Lung 489 1,514 1.47TB
All Three 639 2,071 2TB