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Trial Summary

About CDAS Project, PI, Publications: Risk of multiple myeloma in relation to plasma adipokine levels: a nested case-control study in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Datasets


Site: Lymphoid

Inclusion Criteria:

  • No Rare Cancers
  • Tested for MGUS in Previous Study
  • Serum Available
  • Serum Available from Same Study Year as MGUS Sample

Matching Factors:

  • Gender
  • Race (W/B/O)
  • Study Year of Draw
  • Age at Draw
  • Date of Draw

Match Ratio: 3:1

Match Technique: Individual matching only non-cases as controls.

Additional Matching Comments: Draw age +/- 2 years and draw date +/- 90 days were considered optimal. These were progressively loosened to attain matches. 8 case sets are incomplete due to age/date of draw proximity being inadequate.


Analytes:

  • Adiponectin
  • High-Molecular Weight Adiponectin

Number of Cases: 79

Number of Controls: 229




Site: Lymphoid

Inclusion Criteria:

  • No Prior History of Any Cancer
  • No Rare Cancers in Controls
  • Heparin Plasma Available
  • Pre-DX Heparin Plasma Available
  • Cases: Incident Cancers Only

Matching Factors:

  • Gender
  • Race (5 levels, combined minorities)
  • Time of Blood Draw (am/pm)
  • Entry Season and Year
  • Age at Randomization (5 year intervals)
  • Study Year of Blood Draw

Match Ratio: 2-to-1

Match Technique: Individual matching with replacement and cases as controls.

Additional Matching Comments: The cases and controls were split into tree categories: 2009-00506 cases/controls, 'clean' cases/controls (1st cancers), and 'dirty' cases/controls (1st MM/Lymphoma dx). The controls were then rematched to GWAS subjects (without replacement).


Analytes:

  • Adiponectin
  • High-Molecular Weight Adiponectin
  • Leptin

Number of Cases: 174

Number of Controls: 348