Site: Lymphoid

Inclusion Criteria:

• No Rare Cancers
• Tested for MGUS in Previous Study
• Serum Available
• Serum Available from Same Study Year as MGUS Sample

Matching Factors:

• Gender
• Race (W/B/O)
• Study Year of Draw
• Age at Draw
• Date of Draw

Match Ratio: 3:1

Match Technique: Individual matching only non-cases as controls.

Additional Matching Comments: Draw age +/- 2 years and draw date +/- 90 days were considered optimal. These were progressively loosened to attain matches. 8 case sets are incomplete due to age/date of draw proximity being inadequate.

Analytes:

• Adiponectin
• High-Molecular Weight Adiponectin

Number of Cases: 79

Number of Controls: 229

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Site: Lymphoid

Inclusion Criteria:

• No Prior History of Any Cancer
• No Rare Cancers in Controls
• Heparin Plasma Available
• Pre-DX Heparin Plasma Available
• Cases: Incident Cancers Only

Matching Factors:

• Gender
• Race (5 levels, combined minorities)
• Time of Blood Draw (am/pm)
• Entry Season and Year
• Age at Randomization (5 year intervals)
• Study Year of Blood Draw

Match Ratio: 2-to-1

Match Technique: Individual matching with replacement and cases as controls.

Additional Matching Comments: The cases and controls were split into tree categories: 2009-00506 cases/controls, 'clean' cases/controls (1st cancers), and 'dirty' cases/controls (1st MM/Lymphoma dx). The controls were then rematched to GWAS subjects (without replacement).

Analytes:

• Adiponectin
• High-Molecular Weight Adiponectin
• Leptin

Number of Cases: 174

Number of Controls: 348

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