Site: Endometrial

Inclusion Criteria:

• Females in Intervention Arm
• No Rare Cancers
• No Prior History of Any Cancer
• No Confirmed or Reported Cancers in Controls
• No Hysterectomy
• No Endometrial Cancers that are 2nd, reported, or unconfirmable
• Has Any Serum Available
• Has Pre-dx Serum Available
• Frequency Matched at a 1-1 Ratio

Matching Factors:

• Fiscal Year of Randomization
• Age at Randomization (5 year intervals)
• Race (White/Non-White)
• Study Year of Blood Draw
• Study Year of Exit

Match Ratio: 1 to 1

Match Technique: Frequency matching only non-cases as controls.

Analytes:

• Adiponectin
• Adipsin
• B-Cell Attracting Chemokine 1
• Basic Fibroblast Growth Factor
• C-Reactive Protein
• Chemokine (C-C Motif) Ligand 13
• Chemokine (C-C Motif) Ligand 19
• Chemokine (C-C Motif) Ligand 2
• Chemokine (C-C Motif) Ligand 20
• Chemokine (C-C Motif) Ligand 21
• Chemokine (C-C Motif) Ligand 22
• Chemokine (C-C Motif) Ligand 27
• Chemokine (C-C Motif) Ligand 8
• Chemokine (C-X-C Motif) Ligand 1
• Chemokine (C-X-C Motif) Ligand 10
• Chemokine (C-X-C Motif) Ligand 11
• Chemokine (C-X-C Motif) Ligand 12
• Chemokine (C-X-C Motif) Ligand 5
• Chemokine (C-X-C Motif) Ligand 6
• Chemokine (C-X-C Motif) Ligand 9
• Eotaxin
• Eotaxin-2
• Epidermal Growth Factor
• Estradiol
• Granulocyte-Colony Stimulating Factor
• Interleukin 1
• Interleukin 1 Receptor Antagonist
• Interleukin 16
• Interleukin 29
• Interleukin 33
• Interleukin 7
• Interleukin 8
• Lipocalin-2
• Macrophage Inflammatory Protein 1 delta
• Macrophage inflammatory protein 1 beta
• Plasminogen activator inhibitor-1
• Resistin
• Serum Amyloid A
• Serum Amyloid P
• Soluble Epidermal Growth Factor Receptor
• Soluble Interleukin 4 Receptor
• Soluble Interleukin 6 Receptor
• Soluble Interleukin 6 beta
• Soluble Tumor Necrosis Factor Receptor I
• Soluble Tumor Necrosis Factor Receptor II
• Stem Cell Factor
• Thrombopoietin
• Thymic Stromal Lymphopoietin
• Thymus and Activation Regulated Chemokine
• Transforming Growth Factor Alpha
• Transforming Growth Factor Beta 1
• Tumor Necrosis Factor Alpha 1
• Tumor Necrosis Factor Beta
• Tumor Necrosis Factor Receptor Superfamily, Member 10
• Vascular Endothelial Growth Factor
• Vascular endothelial growth factor receptor 2
• Vascular endothelial growth factor receptor 3

Number of Cases: 284

Number of Controls: 284

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Site: Ovary

Inclusion Criteria:

• Females in Intervention Arm
• No Rare Cancers in Controls
• No Controls with Oophorectomies
• 2+ Years Pre-Diagnostic Specimen Available

Matching Factors:

• Age at Randomization (5 year intervals)
• Race
• Study Year of Blood Draw
• Year of Blood Draw
• Season of Blood Draw
• Time of Blood Draw (am/pm)

Match Ratio: 1 to 1

Match Technique: Case cohort with controls matched to cases.

Additional Matching Comments: One cell had no matched controls; the case was kept.

Analytes:

• Amylin
• Basic Fibroblast Growth Factor
• C-Peptide
• C-Reactive Protein
• Chemokine (C-C Motif) Ligand 2
• Chemokine (C-C Motif) Ligand 22
• Chemokine (C-X-C Motif) Ligand 1
• Chemokine (C-X-C Motif) Ligand 10
• Chemokine (C-X3-C Motif) Ligand 1
• Chemokine Ligand 7
• Eotaxin
• Epidermal Growth Factor
• Fms-related tyrosine kinase 3 ligand
• Gastric inhibitory polypeptide
• Glucagon
• Glucagon-like peptide-1
• Granulocyte-Colony Stimulating Factor
• Granulocyte-Macrophage Colony Stimulating Factor
• Insulin
• Interferon alpha-2
• Interferon-gamma
• Interleukin 1
• Interleukin 1 Receptor Antagonist
• Interleukin 1 alpha
• Interleukin 1 beta
• Interleukin 10
• Interleukin 12 p40
• Interleukin 12 p70
• Interleukin 15
• Interleukin 17
• Interleukin 2
• Interleukin 3
• Interleukin 4
• Interleukin 5
• Interleukin 6
• Interleukin 7
• Interleukin 8
• Leptin
• Macrophage Inflammatory Protein 1 alpha
• Macrophage inflammatory protein 1 beta
• Pancreatic Polipeptide
• Pancreatic Polipeptide YY
• Soluble Epidermal Growth Factor Receptor
• Soluble Interleukin 1 Receptor Type 1
• Soluble Interleukin 2 Receptor Alpha
• Soluble Interleukin 4 Receptor
• Soluble Interleukin 6 Receptor
• Soluble Interleukin 6 beta
• Soluble Receptor for Advanced Glycation Endproducts
• Soluble Tumor Necrosis Factor Receptor I
• Soluble Tumor Necrosis Factor Receptor II
• Transforming Growth Factor Alpha
• Tumor Necrosis Factor Alpha 1
• Tumor Necrosis Factor Beta
• Tumor Necrosis Factor Receptor Superfamily, Member 5
• Tumor Necrosis Factor Receptor Superfamily, Member 8
• Vascular Endothelial Growth Factor
• Vascular endothelial growth factor receptor 1
• Vascular endothelial growth factor receptor 2
• Vascular endothelial growth factor receptor 3

Number of Cases: 150

Number of Controls: 169

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