Site: Colorectal

Inclusion Criteria:

• All I-Arm
• T0 Negative or Colon Negative
• With Signature
• DNA/Source Available
• No Previous Colon Disease
• Adequate T3/5 Screen
• T5 FSG Before 10/01/2003
• 5 Vials of T0 Serum
• Selected Population Genotype Population
• No Cancer Prior to T3/5 Screen
• Has 2 Vials of T0 Serum
• No Confirmed Cancer (Selected Biochemical Population)

Matching Factors:

• Age at Randomization (5 year intervals)
• Race
• Fiscal Year of Randomization
• Gender
• Protocol (T3/T5)

Match Ratio: 1 to 1

Match Technique: Frequency matching only non-cases as controls.

Additional Matching Comments: Matching was done on the genetic component of this study. The biochemical portion is the subset of that match with available serum.

Analytes:

• C-Reactive Protein
• Ferritin
• Iron
• SE Fat Percent
• Total Iron Binding Capacity
• Unsaturated Iron Binding Capacity

Number of Cases: 356

Number of Controls: 396

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Site: Colorectal

Inclusion Criteria:

• All I-Arm
• agg_left in (0,1) [potential cases and controls]
• rnddate < 10/99
• Successful FSG
• No Previous Colon Disease
• Has T0 or T3 Blood
• Has Sig1
• Selected for nested case/control

Matching Factors:

• Gender
• Race

Match Ratio: 1 to 1

Match Technique: Frequency matched, non-cases as controls only

Additional Matching Comments: Prevalent advanced adenoma cases were matched to non-cases at a 1-1 ratio without replacement

Analytes:

• Insulin-like Growth Factor 1
• Insulin-like Growth Factor 2
• Insulin-like Growth Factor Binding Protein 3

Number of Cases: 770

Number of Controls: 777

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