Site: Prostate

Inclusion Criteria:

• All I-Arm Men
• No Prior History of Prostate Cancer
• White, Non-Hispanic
• Not From Hawaii Center
• No Rare Cancers in Controls
• Perfect Serum at T0 or .5+ ml child or in 2008-256,2009-555, or 2009-565
• Incident (Cases Only)
• In Prostate BPC3 Biochemical
• In Final Population (Original Selection Line)
• Has .5ml of Serum Available
• Updated Advanced Case or Updated Control
• Updated Case with Age at Dx <= 70 or Updated Control
• Exclude All Rare Cancers
• No Controls With no Results
• Matched Cases at a 1-1 Ratio

Matching Factors:

• Age at Randomization (5 year intervals)
• Original Draw Year

Match Ratio: 1 to 1

Match Technique: Frequency matching only non-cases as controls.

Analytes:

• 16-Epiestriol
• 16-Ketoestradiol
• 16Alpha-Hydroxyestrone
• 17-Epiestriol
• 2-Hydroxyestradiol
• 2-Hydroxyestrone
• 2-Hydroxyestrone-3-Methyl Ether
• 2-Methoxyestradiol
• 2-Methoxyestrone
• 4-Hydroxyestrone
• 4-Methoxyestradiol
• 4-Methoxyestrone
• Estradiol
• Estriol
• Estrone

Number of Cases: 195

Number of Controls: 195

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