Browse Lab Results > 2009-0553

Site: Breast

Inclusion Criteria:

• Intervention Arm Females
• No Prior History of Any Cancer
• No Erroneous/Unconfirmable/In situ Breast Cancers
• No Rare Cancers
• No Reports of Any Cancer During Trial (other than breast for cases)
• In 2005-007 Genotype Population
• With Unchanged Case Definition
• Extracted DNA Available or T0 Buffy Coat
• Pre-Exit Extracted DNA/T0 Buffy Coat
• Pre-Exit Extracted DNA/T0 Buffy Coat 1+ Years Pre-Dx (Cases)
• Cases Limited to Target Group

Matching Factors:

• Age at Randomization (5 year intervals)
• Fiscal Year of Randomization (<=1997, >1997)
• DNA Material Type (Source/Extracted)
• Study Year of Blood Draw

Match Ratio: 1:1

Match Technique: Frequency matching only non-cases as controls.

Additional Matching Comments: Most distal extracted DNA was taken for cases, if available. T0 buffy coat was taken for the remaining cases.

Analytes:

• 2'-deoxyguanine concentration
• 5-methyl-22-deoxycytidine concentration
• 5-methyl-22-deoxycytidine to 2'-deoxyguanine percent
• 5-methyl-22-deoxycytidine to 2'-deoxyguanine ratio
• Average 2'-deoxyguanine concentration
• Average 5-methyl-22-deoxycytidine
• Average 5-methyl-22-deoxycytidine to 2'-deoxyguanine percent

Number of Cases: 430

Number of Controls: 426

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