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Browse Lab Results > 2009-0553

Trial Summary

About CDAS Project, PI, Publications: Epigenotyping in Peripheral Blood Cell DNA and Risk of Breast Cancer

Datasets


Site: Breast

Inclusion Criteria:

  • Intervention Arm Females
  • No Prior History of Any Cancer
  • No Erroneous/Unconfirmable/In situ Breast Cancers
  • No Rare Cancers
  • No Reports of Any Cancer During Trial (other than breast for cases)
  • In 2005-007 Genotype Population
  • With Unchanged Case Definition
  • Extracted DNA Available or T0 Buffy Coat
  • Pre-Exit Extracted DNA/T0 Buffy Coat
  • Pre-Exit Extracted DNA/T0 Buffy Coat 1+ Years Pre-Dx (Cases)
  • Cases Limited to Target Group

Matching Factors:

  • Age at Randomization (5 year intervals)
  • Fiscal Year of Randomization (<=1997, >1997)
  • DNA Material Type (Source/Extracted)
  • Study Year of Blood Draw

Match Ratio: 1:1

Match Technique: Frequency matching only non-cases as controls.

Additional Matching Comments: Most distal extracted DNA was taken for cases, if available. T0 buffy coat was taken for the remaining cases.


Analytes:

  • 2'-deoxyguanine concentration
  • 5-methyl-22-deoxycytidine concentration
  • 5-methyl-22-deoxycytidine to 2'-deoxyguanine percent
  • 5-methyl-22-deoxycytidine to 2'-deoxyguanine ratio
  • Average 2'-deoxyguanine concentration
  • Average 5-methyl-22-deoxycytidine
  • Average 5-methyl-22-deoxycytidine to 2'-deoxyguanine percent

Number of Cases: 430

Number of Controls: 426