Site: Lung

Inclusion Criteria:

• No Baseline Questionnaire Cancer
• No Other Cancer
• Valid Smoking History

Matching Factors:

• Gender
• Smoking History
• Packyears
• Year of Randomization (Grouped)
• Age at Randomization (5 year intervals)

Match Ratio: 3 to 1 for non-smokers, 1 to 1 for former/current smokers

Match Technique: Frequency matching with replacement and cases as controls (Incidence Density)

Analytes:

• Interleukin 1 beta
• Interleukin 6
• Interleukin 8
• Mannan-binding lectin
• Mannan-binding lectin serine protease 2
• Tumor Necrosis Factor Alpha

Number of Cases: 593

Number of Controls: 649

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