Site: Lung

Inclusion Criteria:

• Valid Smoking History
• No Prior History of Lung Cancer
• Not in 2009-00516 Scarring
• No Rare Cancer
• No Self Report/Unconfirmable Lung Cancer in Controls
• Serum Available
• Pre-Diagnostic Serum Available
• Serum Available 1-10 Years Before Diagnosis
• Cases With Similar Time from Draw to Diagnosis as Cases in 2009-00516

Matching Factors:

• Gender
• Age at Randomization (5 year intervals)
• Calendar Year of Blood Draw (2 year intervals)
• Study Year of Blood Draw
• Smoking History
• Years Since Quit Smoking (<15, 15+)
• Pack Years Smoked (<30, 30-40, 40-50,50+)

Match Ratio: 1:1 for ever smokers, 3:1 for never smokers

Match Technique: Individual matching only non-cases as controls.

Additional Matching Comments: GWAS controls were rematched to selected controls without a GWAS on all matching factors, as well as race (3 levels) and cancer experience.

Analytes:

• B-Cell Attracting Chemokine 1
• Basic Fibroblast Growth Factor
• C-Reactive Protein
• Chemokine (C-C Motif) Ligand 13
• Chemokine (C-C Motif) Ligand 19
• Chemokine (C-C Motif) Ligand 2
• Chemokine (C-C Motif) Ligand 20
• Chemokine (C-C Motif) Ligand 21
• Chemokine (C-C Motif) Ligand 22
• Chemokine (C-C Motif) Ligand 27
• Chemokine (C-C Motif) Ligand 8
• Chemokine (C-X-C Motif) Ligand 1
• Chemokine (C-X-C Motif) Ligand 10
• Chemokine (C-X-C Motif) Ligand 11
• Chemokine (C-X-C Motif) Ligand 12
• Chemokine (C-X-C Motif) Ligand 5
• Chemokine (C-X-C Motif) Ligand 6
• Chemokine (C-X-C Motif) Ligand 9
• Eotaxin
• Eotaxin-2
• Epidermal Growth Factor
• Granulocyte-Colony Stimulating Factor
• Interleukin 1
• Interleukin 1 Receptor Antagonist
• Interleukin 16
• Interleukin 29
• Interleukin 3
• Interleukin 33
• Interleukin 7
• Interleukin 8
• Macrophage Inflammatory Protein 1 delta
• Macrophage inflammatory protein 1 beta
• Serum Amyloid A
• Serum Amyloid P
• Soluble Epidermal Growth Factor Receptor
• Soluble Interleukin 4 Receptor
• Soluble Interleukin 6 Receptor
• Soluble Interleukin 6 beta
• Soluble Tumor Necrosis Factor Receptor I
• Soluble Tumor Necrosis Factor Receptor II
• Stem Cell Factor
• Thrombopoietin
• Thymic Stromal Lymphopoietin
• Thymus and Activation Regulated Chemokine
• Transforming Growth Factor Alpha
• Tumor Necrosis Factor Alpha 1
• Tumor Necrosis Factor Beta
• Tumor Necrosis Factor Receptor Superfamily, Member 10
• Vascular Endothelial Growth Factor
• Vascular endothelial growth factor receptor 2
• Vascular endothelial growth factor receptor 3

Number of Cases: 526

Number of Controls: 626

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