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Approved PLCO Projects

Here you can browse the complete list of projects for PLCO whose requests for data/biospecimens were approved.

Filter results of approved projects table below

Showing Most Recent
1-20 of 1725
Approved Projects
Name Principal Investigator Institution Study Date Approved Project ID
Outcomes of men aged ≥60 years old with moderately elevated PSA (1–20 ng/mL) in the PLCO cancer screening trial Scott Eggener University of California, Los Angeles PLCO Oct 5, 2026 PLCO-2084
Incidence of Upper Tract Urothelial Carcinoma in Relation to Smoking, Analgesic Use, and Medical History in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Jonathan Hofmann Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health PLCO Sep 28, 2026 PLCO-2085
Quantitative Analysis of H&E Histopathology and Cancer Outcomes in PLCO James Kelley Pictor Labs. Inc. PLCO Sep 28, 2026 PLCOI-2081
Analytical Suitability and Storage-Stability Pilot for a Serum NMR-Based Multi-Omics Multi-Cancer Early Detection Assay Using Pre-Diagnostic PLCO Specimens PATRICK STRASSER Wholomics GmbH PLCO Sep 15, 2026 2026-0185
The Population Attributable Fractions of Pancreatic Cancer Caused by Key Risk Factors (continuation of PLCO-351) Rachael Stolzenberg-Solomon NCI, NIH PLCO Sep 10, 2026 PLCO-2083
Quantifiable TCR repertoire changes in pre-diagnostic blood specimens among high-grade ovarian cancer patients Bo Li Children's Hospital of Philadelphia PLCO Sep 10, 2026 2025-0079
Integration of omics data and lifestyle factors to assess lung cancer risk among former smokers Xiao Ou Shu Vanderbilt University Medical Center PLCO Sep 10, 2026 2025-0054
Prostate Cancer Risk Stratification Using Needle Core Biopsy or Radical Prostatectomy Specimens (Continuation of PLCOI-2074) Uttara Joshi AIRA Matrix Private Limited PLCO Sep 8, 2026 PLCOI-2080
Evaluating the Impact of Differential LDCT Screening Uptake, Adherence, and Novel Treatment Access on Racial/Ethnic Disparities in Lung Cancer Outcomes: A Modeling Study Michael Leo Oregon Health & Science University PLCO Sep 8, 2026 PLCO-2072
Artificial Intelligence (AI)-Assisted Health Informatics to Stratify Population for Early Screening of Cancer (Sibling Project to PLCO-2067) Gregory Hart University of Guam PLCO Aug 31, 2026 PLCO-2078
Evaluate Artera’s Deep Learning clinical-histologic system as a prognostic classifier for colorectal cancer patients Douglas Peters Artera Inc. PLCO Aug 24, 2026 PLCOI-2073
External Validation of Foundation Model-Derived Histologic Phenotypes in Prostate Pathology Images Olmo Zavala Romero Florida State University PLCO Aug 24, 2026 PLCOI-2063
Digital Twin–Enabled Prediction of Toxicity and Tumor Control in Prostate Cancer Radiotherapy Samantha Rincon Sabatino InfotechSoft PLCO Aug 24, 2026 PLCOI-2075
Machine Learning to Refine Breast Staging for Prediction of Axillary Node Status and Prognosis Mark Sherman Mayo Clinic, Jacksonville, Florida PLCO Aug 10, 2026 PLCOI-2066
Virtual Staining–Enabled Macrophage Profiling in Ovarian & Lung Cancer Anant Madabhushi Emory University PLCO Jul 27, 2026 PLCOI-2068
Adherence to the 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations and risk of mortality in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial Fiona Malcomson Newcastle University PLCO Jul 27, 2026 PLCO-2069
AEGIS — AI-Enabled Genomic and Integrated Stratification for Multi-Cancer Risk: Deep-Learning Development and Internal Validation in the PLCO Cohort Aneel Paulus West Eastern Health PLCO Jul 14, 2026 PLCO-2064
Development of generalizable pathology foundation models for cancer prognosis using PLCO whole slide images Marvin Lerousseau Spotlight Medical, SAS PLCO Jul 14, 2026 PLCOI-2060
External Validation of a Deep-Learning Atypical Mitosis Based Prognostic Model Using the PLCO Pathology Image Repository William Chen University of California, San Francisco PLCO Jul 14, 2026 PLCOI-2059
Developing a risk prediction model for future colorectal neoplasia AASMA SHAUKAT NYU Langone Health PLCO Jul 14, 2026 PLCOI-2062