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Browse Lab Results > 2014-0037

Trial Summary

About CDAS Project, PI, Publications: Expanded evaluation of markers of human papillomavirus (HPV) infection and cancer at multiple anatomic sites - using PLCO data to bolster the cohort consortium effort

Datasets


Site: Multiple

Inclusion Criteria:

  • All I-Arm
  • Has Biochemical Consent
  • No Rare Cancers in Non-Cases
  • Has Followup Time (At least 1 day)
  • Not in 2011-0281 or 2014-0037
  • Has Any Serum
  • Has Pre-DX Material
  • Matched at a 2-1 Ratio

Matching Factors:

  • Gender
  • Age at randomization (5 year groups)
  • Race (W/B/O)
  • Year of birth (5 year groups)
  • Year of blood draw

Match Ratio: 2 to 1

Match Technique: Frequency matching only non-cases as controls.

Additional Matching Comments: 2-1 match accounting for the selection of serial samples


Analytes:

  • HPV 11E6
  • HPV 11E7
  • HPV 11L1
  • HPV 16E1 FL
  • HPV 16E2
  • HPV 16E4
  • HPV 16E6
  • HPV 16E7
  • HPV 16L1
  • HPV 18E1 FL
  • HPV 18E2
  • HPV 18E4
  • HPV 18E6
  • HPV 18E7
  • HPV 18L1
  • HPV 31E6
  • HPV 31E7
  • HPV 31L1
  • HPV 33E6
  • HPV 33E7
  • HPV 33L1
  • HPV 35E6
  • HPV 35E7
  • HPV 35L1
  • HPV 45E6
  • HPV 45E7
  • HPV 45L1
  • HPV 52E6
  • HPV 52E7
  • HPV 52L1
  • HPV 58E6
  • HPV 58E7
  • HPV 58L1
  • HPV 6BE6
  • HPV 6BE7
  • HPV 6L1
  • Herpes Simplex Virus 2 2mgG unique
  • Human Polyomavirus BK VP1
  • Human Polyomavirus HPyV6 VP1
  • Human Polyomavirus JC VP1
  • Tumor Protein P53

Number of Cases: 139

Number of Controls: 278



Site: Anogenital

Inclusion Criteria:

  • All I-Arm
  • Has Biochemical Consent
  • No Prior History of Cancer
  • No Rare Cancers in Controls
  • Has Follow-up Time (at least 1 day)
  • Has Serum
  • Has Pre-DX Serum (Eligible)
  • Matched 4-1 (Selected)

Matching Factors:

  • Gender
  • Race (White/Black/Other)
  • Year of Birth
  • Study Year of Exit
  • Study Year of Material
  • Draw Date in 6 Month Blocks

Match Ratio: 4 to 1

Match Technique: Frequency matching only non-cases as controls.


Analytes:

  • Cell Protein P16
  • Epstein-Barr Virus EA-D
  • Epstein-Barr Virus EBNA truncated
  • Epstein-Barr Virus VCA p18
  • Epstein-Barr Virus Zebra
  • HPV 11E6
  • HPV 11E7
  • HPV 11L1
  • HPV 16E1 FL
  • HPV 16E2
  • HPV 16E6
  • HPV 16E7
  • HPV 16L1
  • HPV 18E6
  • HPV 18E7
  • HPV 18L1
  • HPV 1L1
  • HPV 31E6
  • HPV 31E7
  • HPV 31L1
  • HPV 33E6
  • HPV 33E7
  • HPV 33L1
  • HPV 45E6
  • HPV 45E7
  • HPV 45L1
  • HPV 52E6
  • HPV 52E7
  • HPV 52L1
  • HPV 58E6
  • HPV 58E7
  • HPV 58L1
  • HPV 6BE2
  • HPV 6BE6
  • HPV 6BE7
  • HPV 6L1
  • HPV 8L1
  • Herpes Simplex Virus 2 2mgG unique
  • Human Polyomavirus BK VP1
  • Human Polyomavirus JC VP1
  • Tumor Protein P53

Number of Cases: 73

Number of Controls: 292



Site: Head and Neck

Inclusion Criteria:

  • All I-Arm
  • BQ Returned
  • Has Biochemical Consent
  • Has Any Serum
  • Has Pre-DX Material
  • In Desired Population
  • Has Pre-DX Serum in Unmeasured Year

Matching Factors:

  • N
  • o
  • n
  • e

Match Ratio: Not Applicable

Match Technique: Not Applicable


Analytes:

  • Cell Protein P16
  • Epstein-Barr Virus EA-D
  • Epstein-Barr Virus EBNA truncated
  • Epstein-Barr Virus Zebra
  • HPV 11E6
  • HPV 11E7
  • HPV 11L1
  • HPV 16E1 FL
  • HPV 16E2
  • HPV 16E4
  • HPV 16E6
  • HPV 16E7
  • HPV 16L1
  • HPV 18E1 FL
  • HPV 18E2
  • HPV 18E4
  • HPV 18E6
  • HPV 18E7
  • HPV 18L1
  • HPV 31E6
  • HPV 31E7
  • HPV 31L1
  • HPV 33E6
  • HPV 33E7
  • HPV 33L1
  • HPV 45E6
  • HPV 45E7
  • HPV 45L1
  • HPV 58E6
  • HPV 58E7
  • HPV 58L1
  • HPV 6BE2
  • HPV 6BE6
  • HPV 6BE7
  • HPV 6L1
  • Hepatitis C Virus 1aCore (1.4)
  • Hepatitis C Virus 1aNS3 (2.5)
  • Herpes Simplex Virus 2 2mgG unique
  • Human Polyomavirus BK VP1
  • Human Polyomavirus JC VP1
  • Tumor Protein P53

Number of Cases: 73

Number of Controls: 8