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Browse Lab Results > 2012-0356

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Trial Summary

About CDAS Project, PI, Publications: Circulating inflammation markers and risk of lung cancer: A replication study

Datasets

Site: Lung

Inclusion Criteria:

  • Valid Smoking History
  • No Prior History of Lung Cancer
  • Not in 2009-00516 Scarring
  • No Rare Cancer
  • No Self Report/Unconfirmable Lung Cancer in Controls
  • Serum Available
  • Pre-Diagnostic Serum Available
  • Serum Available 1-10 Years Before Diagnosis
  • Cases With Similar Time from Draw to Diagnosis as Cases in 2009-00516

Matching Factors:

  • Gender
  • Age at Randomization (5 year intervals)
  • Calendar Year of Blood Draw (2 year intervals)
  • Study Year of Blood Draw
  • Smoking History
  • Years Since Quit Smoking (<15, 15+)
  • Pack Years Smoked (<30, 30-40, 40-50,50+)

Match Ratio: 1:1 for ever smokers, 3:1 for never smokers

Match Technique: Individual matching only non-cases as controls.

Additional Matching Comments: GWAS controls were rematched to selected controls without a GWAS on all matching factors, as well as race (3 levels) and cancer experience.

Analytes:

  • B-Cell Attracting Chemokine 1
  • Basic Fibroblast Growth Factor
  • C-Reactive Protein
  • Chemokine (C-C Motif) Ligand 13
  • Chemokine (C-C Motif) Ligand 19
  • Chemokine (C-C Motif) Ligand 2
  • Chemokine (C-C Motif) Ligand 20
  • Chemokine (C-C Motif) Ligand 21
  • Chemokine (C-C Motif) Ligand 22
  • Chemokine (C-C Motif) Ligand 27
  • Chemokine (C-C Motif) Ligand 8
  • Chemokine (C-X-C Motif) Ligand 1
  • Chemokine (C-X-C Motif) Ligand 10
  • Chemokine (C-X-C Motif) Ligand 11
  • Chemokine (C-X-C Motif) Ligand 12
  • Chemokine (C-X-C Motif) Ligand 5
  • Chemokine (C-X-C Motif) Ligand 6
  • Chemokine (C-X-C Motif) Ligand 9
  • Eotaxin
  • Eotaxin-2
  • Epidermal Growth Factor
  • Granulocyte-Colony Stimulating Factor
  • Interleukin 1
  • Interleukin 1 Receptor Antagonist
  • Interleukin 16
  • Interleukin 29
  • Interleukin 3
  • Interleukin 33
  • Interleukin 7
  • Interleukin 8
  • Macrophage Inflammatory Protein 1 delta
  • Macrophage inflammatory protein 1 beta
  • Serum Amyloid A
  • Serum Amyloid P
  • Soluble Epidermal Growth Factor Receptor
  • Soluble Interleukin 4 Receptor
  • Soluble Interleukin 6 Receptor
  • Soluble Interleukin 6 beta
  • Soluble Tumor Necrosis Factor Receptor I
  • Soluble Tumor Necrosis Factor Receptor II
  • Stem Cell Factor
  • Thrombopoietin
  • Thymic Stromal Lymphopoietin
  • Thymus and Activation Regulated Chemokine
  • Transforming Growth Factor Alpha
  • Tumor Necrosis Factor Alpha 1
  • Tumor Necrosis Factor Beta
  • Tumor Necrosis Factor Receptor Superfamily, Member 10
  • Vascular Endothelial Growth Factor
  • Vascular endothelial growth factor receptor 2
  • Vascular endothelial growth factor receptor 3

Number of Cases: 526

Number of Controls: 626