The following updates were made to the PLCO datasets available on CDAS:

• More events and follow-up time
  • Cancer diagnoses are now censored at December 31, 2009
  • Deaths are now censored at December 31, 2015
  • Exit status updated to account for new cutoffs (note formats differ from previous versions)
• In 2011, a process was initiated to have active follow-up of PLCO participants at a Centralized Data Collection Center (CDCC). A new variable reconsent_outcome was added to summarize the outcome of this transfer and re-consent process.
• New Main Questionnaire data added
  • Medication Use Questionnaire (MUQ)
• Changes were made to make like variables more consistent
  • Site specific cancer variables are now [site]_cancer instead of cancer_[site]
  • Personal history variables are now ph_[site]_[qx] instead of [qx]_cohort_[site]
  • Death variables now start with d_ instead of dcf_
  • Staging formats were updated to all be consistent.

The total population now has 154,887 participants. Over the course of the trial this number decreases due to participants withdrawing, improper consent at randomization or duplication at randomization.

The following updates were made to the PLCO datasets available on CDAS:

• New Main Questionnaire data added: Medication Use Questionnaire

Requests for Specimen Verification will only be accepted from May 15 to July 15, 2019 . If you plan to submit a grant application this cycle, an approved Request for Specimen Verification is required. Once your Request for Specimen Verification has been approved, you will receive a confirmation letter to accompany your grant application.

The grant application deadline is August 14, 2019.

Information is available regarding the PLCO trial and PLCO biospecimens

Please visit the PAR Request Form for Specimen Verification page to preview instructions about the process, review the Policies and Procedures, and begin a Request for Specimen Verification.

If you have any questions, please contact CDAS staff at cdas-eems@imsweb.com.

Preliminary applications will only be accepted from February 22 to August 15, 2019. If you plan to submit an EEMS application this cycle, an approved preliminary application is required. Once your preliminary application has been approved, you will be notified and you will be able to continue and submit a full application.

The full application deadline is October 1, 2019. The full applications will undergo panel review and final outcome notifications will be sent in early December 2019.

Information is available regarding the PLCO trial and PLCO biospecimens.

Please visit the EEMS Application for Biospecimens page to preview instructions about the process, review the EEMS Policies and Procedures, and begin an EEMS Preliminary Application for Biospecimens.

If you have any questions, please contact CDAS staff at cdas-eems@imsweb.com.

Preliminary applications will only be accepted through February 15, 2019. If you plan to submit an EEMS application this cycle, an approved preliminary application is required. Once your preliminary application has been approved, you will be notified and you will be able to continue and submit a full application.

The full application deadline is April 2, 2019. The full applications will undergo panel review and final outcome notifications will be sent in early July 2019.

Information is available regarding the PLCO trial and PLCO biospecimens.

Please visit the EEMS Application for Biospecimens page to preview instructions about the process, review the EEMS Policies and Procedures, and begin an EEMS Preliminary Application for Biospecimens.

If you have any questions, please contact CDAS staff at cdas-eems@imsweb.com.