Repeated measures of metabolomic profiles and pancreatic cancer in PLCO
We have approval (EEMS 2012-00066) for a nested case-control study that uses baseline T0 samples with the aim to replicate the results observed in the ATBC cohort in an independent nested case-control study and pool results. The present study builds upon the approved study by utilizing serial blood collections. In total, the proposed study will include one serial serum sample closest to the time the case was diagnosed from 262 cases and controls with T0 baseline serum measured in EEMS 2012-00066.
Primary aim:
1) To determine whether changes in metabolite concentrations over time are associated with future diagnosis of PDA. We hypothesize that changes in unique metabolites and metabolomics profiles will be associated with PDA.
Secondary aim:
1) To determine whether metabolite concentrations are associated with early-stage and late stage PDA. Here, we will examine associations stratified by time since blood draw. We will conduct an association study, using a non-targeted approach to identify serum metabolites associated with early stage PDA among blood samples collected more than 5 years prior to cancer diagnosis and late stage disease among blood samples collected within 5 years of cancer diagnosis. We hypothesize that unique metabolites and metabolomics profiles will be correspond with different stages of PDA.
Andriy Derkach, Ph.D., M.S. (DCEG,NCI)
Steve Moore,, Ph.D. (DCEG, NCI)
Rachael Solomon, Ph.D., R.D. (DCEG,NCI)
Joshua Sampson, Ph.D., M.S. (DCEG,NCI)
- Lipidomics reliability pilot study
- Lipidomics reliability pilot study II
- replacement serum for lipidomic measures
-
Lipidomics and pancreatic cancer risk in two prospective studies.
Naudin S, Sampson JN, Moore SC, Albanes D, Freedman ND, Weinstein SJ, Stolzenberg-Solomon R
Eur J Epidemiol. 2023 May 12 PUBMED -
Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study.
Stolzenberg-Solomon R, Derkach A, Moore S, Weinstein SJ, Albanes D, Sampson J
Gut. 2020 Feb 14 PUBMED