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Principal Investigator
Name
Sonja Berndt
Degrees
-
Institution
NCI, DCEG, OEEB
Position Title
-
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2005-0011
Initial CDAS Request Approval
Aug 17, 2005
Title
Inflammation regulation: Gene variants and inflammatory markers in colorectal neoplasia
Summary
To determine the relationship between common hapotypes of inflammatory genes and colorectal adenoma and cancer risk. To investigate the association between serum levels of inflammatory markers and colorectal adenoma risk. To determine whether serum inflammatory markers and variants of inflammatory genes modify the relation between energy balance and diet, and colorectal adenoma and cancer risk. To determine whether variants of inflammatory genes modify the relation between energy balance and diet, and colorectal cancer risk.
Aims

To determine the relationship between common hapotypes of inflammatory genes and colorectal adenoma and cancer risk. To investigate the association between serum levels of inflammatory markers and colorectal adenoma risk. To determine whether serum inflammatory markers and variants of inflammatory genes modify the relation between energy balance and diet, and colorectal adenoma and cancer risk. To determine whether variants of inflammatory genes modify the relation between energy balance and diet, and colorectal cancer risk.

Collaborators

Sonja Berndt (NCI, DCEG)
Stephen Chanock (CGF, NCI)
Nilanjan Chatterjee (NCI, DCEG)
Julie Goodman (LHC, CCR, NCI)
Curtis Harris (LHC, CCR, NCI)
Richard Hayes (NCI, DCEG)
Nathaniel Rothman (NCI, DCEG)
Robert Schoen (University of Pittsburgh)
Arthur Schatzkin (NCI, DCEG)
Rashmi Sinha (NCI, DCEG)
Krissta Zanetti (LHC, CCR, NCI)

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