Prostate BPC3
Principal Investigator
Name
Neal Freedman
Degrees
PhD, MPH
Institution
NCI
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
2004-9000
Initial CDAS Request Approval
May 26, 2020
Title
Prostate BPC3
Summary
The Breast and Prostate Cancer and Hormone-Related Gene Variant Study allows large-scale analyses of breast and prostate cancer risk in relation to genetic polymorphisms and gene-environment interactions that affect hormone metabolism. The study combines the resources of six large prospective cohorts from the American Cancer Society (Cancer Prevention Study-II (CPS)), Harvard University (Harvard Cohort Studies), the International Agency for Research on Cancer (European Prospective Investigation into Cancer and Nutrition (EPIC) Study), and the Universities of Hawaii and Southern California (Multiethnic Cohort Study). In addition, two NCI intramural cohorts (Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study are participating.
The study is unique in having prospective plasma samples, genetic material, anthropometric measurements, and extensive questionnaire data on diet, physical activity, exogenous hormone use, smoking, and other lifestyle factors from over 740,000 men and women. Data are drawn from 8,850 patients with prostate cancer and 6,160 patients with breast cancer. Because of the scope and collaborative nature of this consortium, simultaneous investigation of genetic predisposition and lifestyle factors is possible to clarify the inter-relationships between, and the relative importance of, genetic and hormonal risk factors.
Specifically, this study is defining SNPs and haplotypes in steroid hormone metabolizing genes, genes in the insulin-like growh factor (IGF) pathway, and related receptor proteins. These candidate genes are being resequenced in 96 cases of advanced breast cancer, and 96 cases of advanced prostate cancer chosen from the European, African, Latino, Japanese, and Hawaiian-origin ethnic groups. Haplotype tag SNPs are being selected after genotyping of a larger number of SNPs from a collection of 768 samples from the multigenerational CEPH (Centre d'Etude du Polymorphisme Humain) pedigrees and human diversity collection, by the Whitehead Institute for Genome Research and CEPH, and are rapidly being made publicly available.
The interaction of genetic variants with hormonal, lifestyle, and anthropometric factors known to be associated with breast and prostate cancer are being examined. In a subset of studies, the association of these variants with markers of breast and prostate cancer risk (i.e., plasma steroid hormone levels and IGF-1 levels) are being investigated.
Projects developed within the study are fostering continuing interactions between the genomic and epidemiologic research communities, and are integrating the rapid advances in genomic research into large-scale epidemiologic studies. The ultimate goal is to provide the foundation for reducing the public health burden of these cancers.
The study is unique in having prospective plasma samples, genetic material, anthropometric measurements, and extensive questionnaire data on diet, physical activity, exogenous hormone use, smoking, and other lifestyle factors from over 740,000 men and women. Data are drawn from 8,850 patients with prostate cancer and 6,160 patients with breast cancer. Because of the scope and collaborative nature of this consortium, simultaneous investigation of genetic predisposition and lifestyle factors is possible to clarify the inter-relationships between, and the relative importance of, genetic and hormonal risk factors.
Specifically, this study is defining SNPs and haplotypes in steroid hormone metabolizing genes, genes in the insulin-like growh factor (IGF) pathway, and related receptor proteins. These candidate genes are being resequenced in 96 cases of advanced breast cancer, and 96 cases of advanced prostate cancer chosen from the European, African, Latino, Japanese, and Hawaiian-origin ethnic groups. Haplotype tag SNPs are being selected after genotyping of a larger number of SNPs from a collection of 768 samples from the multigenerational CEPH (Centre d'Etude du Polymorphisme Humain) pedigrees and human diversity collection, by the Whitehead Institute for Genome Research and CEPH, and are rapidly being made publicly available.
The interaction of genetic variants with hormonal, lifestyle, and anthropometric factors known to be associated with breast and prostate cancer are being examined. In a subset of studies, the association of these variants with markers of breast and prostate cancer risk (i.e., plasma steroid hormone levels and IGF-1 levels) are being investigated.
Projects developed within the study are fostering continuing interactions between the genomic and epidemiologic research communities, and are integrating the rapid advances in genomic research into large-scale epidemiologic studies. The ultimate goal is to provide the foundation for reducing the public health burden of these cancers.
Aims
Specifically, this study is defining SNPs and haplotypes in steroid hormone metabolizing genes, genes in the insulin-like growh factor (IGF) pathway, and related receptor proteins. These candidate genes are being resequenced in 96 cases of advanced breast cancer, and 96 cases of advanced prostate cancer chosen from the European, African, Latino, Japanese, and Hawaiian-origin ethnic groups. Haplotype tag SNPs are being selected after genotyping of a larger number of SNPs from a collection of 768 samples from the multigenerational CEPH (Centre d'Etude du Polymorphisme Humain) pedigrees and human diversity collection, by the Whitehead Institute for Genome Research and CEPH, and are rapidly being made publicly available.
The interaction of genetic variants with hormonal, lifestyle, and anthropometric factors known to be associated with breast and prostate cancer are being examined. In a subset of studies, the association of these variants with markers of breast and prostate cancer risk (i.e., plasma steroid hormone levels and IGF-1 levels) are being investigated.
Projects developed within the study are fostering continuing interactions between the genomic and epidemiologic research communities, and are integrating the rapid advances in genomic research into large-scale epidemiologic studies. The ultimate goal is to provide the foundation for reducing the public health burden of these cancers.
Collaborators
Neal Freedman (NCI)
Related Publications
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Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3.
Dimitrakopoulou VI, Travis RC, Shui IM, Mondul A, Albanes D, Virtamo J, Agudo A, Boeing H, Bueno-de-Mesquita HB, Gunter MJ, Johansson M, Khaw KT, Overvad K, Palli D, Trichopoulou A, Giovannucci E, Hunter DJ, Lindström S, Willett W, Gaziano JM, ...show more Stampfer M, Berg C, Berndt SI, Black A, Hoover RN, Kraft P, Key TJ, Tsilidis KK
Am. J. Epidemiol. 2017 Mar 15; Volume 185 (Issue 6): Pages 452-464 PUBMED -
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L, CHARGE Longevity Working Group, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YD, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, ...show more Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JA, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kraft P, Li C, Linneberg A, Liu Y, Loos RJ, Body Composition Genetics Consortium, Lorentzon M, Lu Y, Maggio M, Magi R, Meigs J, Mellström D, Nauck M, Newman AB, Pollak MN, Pramstaller PP, Prokopenko I, Psaty BM, Reincke M, Rimm EB, Rotter JI, Saint Pierre A, Schurmann C, Seshadri S, Sjögren K, Slagboom PE, Strickler HD, Stumvoll M, Suh Y, Sun Q, Zhang C, Svensson J, Tanaka T, Tare A, Tönjes A, Uh HW, van Duijn CM, van Heemst D, Vandenput L, Vasan RS, Völker U, Willems SM, Ohlsson C, Wallaschofski H, Kaplan RC
Aging Cell. 2016 Oct; Volume 15 (Issue 5): Pages 811-24 PUBMED -
A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.
Travis RC, Appleby PN, Martin RM, Holly JMP, Albanes D, Black A, Bueno-de-Mesquita HBA, Chan JM, Chen C, Chirlaque MD, Cook MB, Deschasaux M, Donovan JL, Ferrucci L, Galan P, Giles GG, Giovannucci EL, Gunter MJ, Habel LA, Hamdy FC, ...show more Helzlsouer KJ, Hercberg S, Hoover RN, Janssen JAMJL, Kaaks R, Kubo T, Le Marchand L, Metter EJ, Mikami K, Morris JK, Neal DE, Neuhouser ML, Ozasa K, Palli D, Platz EA, Pollak M, Price AJ, Roobol MJ, Schaefer C, Schenk JM, Severi G, Stampfer MJ, Stattin P, Tamakoshi A, Tangen CM, Touvier M, Wald NJ, Weiss NS, Ziegler RG, Key TJ, Allen NE
Cancer Res. 2016 Apr 15; Volume 76 (Issue 8): Pages 2288-2300 PUBMED -
Sexually transmitted infections, benign prostatic hyperplasia and lower urinary tract symptom-related outcomes: results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
Breyer BN, Huang WY, Rabkin CS, Alderete JF, Pakpahan R, Beason TS, Kenfield SA, Mabie J, Ragard L, Wolin KY, Grubb RL, Andriole GL, Sutcliffe S
BJU Int. 2016 Jan; Volume 117 (Issue 1): Pages 145-54 PUBMED -
Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.
Key TJ, Appleby PN, Travis RC, Albanes D, Alberg AJ, Barricarte A, Black A, Boeing H, Bueno-de-Mesquita HB, Chan JM, Chen C, Cook MB, Donovan JL, Galan P, Gilbert R, Giles GG, Giovannucci E, Goodman GE, Goodman PJ, Gunter MJ, ...show more Hamdy FC, Heliövaara M, Helzlsouer KJ, Henderson BE, Hercberg S, Hoffman-Bolton J, Hoover RN, Johansson M, Khaw KT, King IB, Knekt P, Kolonel LN, Le Marchand L, Männistö S, Martin RM, Meyer HE, Mondul AM, Moy KA, Neal DE, Neuhouser ML, Palli D, Platz EA, Pouchieu C, Rissanen H, Schenk JM, Severi G, Stampfer MJ, Tjønneland A, Touvier M, Trichopoulou A, Weinstein SJ, Ziegler RG, Zhou CK, Allen NE, Endogenous Hormones Nutritional Biomarkers Prostate Cancer Collaborative Group
Am. J. Clin. Nutr. 2015 Nov; Volume 102 (Issue 5): Pages 1142-57 PUBMED -
Multivariate piecewise exponential survival modeling.
Li Y, Panagiotou OA, Black A, Liao D, Wacholder S
Biometrics. 2015 Nov PUBMED -
Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.
Cao Y, Lindström S, Schumacher F, Stevens VL, Albanes D, Berndt S, Boeing H, Bueno-de-Mesquita HB, Canzian F, Chamosa S, Chanock SJ, Diver WR, Gapstur SM, Gaziano JM, Giovannucci EL, Haiman CA, Henderson B, Johansson M, Le Marchand L, Palli D, ...show more Rosner B, Siddiq A, Stampfer M, Stram DO, Tamimi R, Travis RC, Trichopoulos D, Willett WC, Yeager M, Kraft P, Hsing AW, Pollak M, Lin X, Ma J
J. Natl. Cancer Inst. 2014 Jun; Volume 106 (Issue 6): Pages dju085 PUBMED -
Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
Tsilidis KK, Travis RC, Appleby PN, Allen NE, Lindström S, Albanes D, Ziegler RG, McCullough ML, Siddiq A, Barricarte A, Berndt SI, Bueno-de-Mesquita HB, Chanock SJ, Crawford ED, Diver WR, Gapstur SM, Giovannucci E, Gu F, Haiman CA, Hayes RB, ...show more Hunter DJ, Johansson M, Kaaks R, Kolonel LN, Kraft P, Le Marchand L, Overvad K, Polidoro S, Riboli E, Schumacher FR, Stevens VL, Trichopoulos D, Virtamo J, Willett WC, Key TJ
Int. J. Cancer. 2013 Jul; Volume 133 (Issue 2): Pages 495-504 PUBMED -
Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to prostate cancer risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Tsilidis KK, Travis RC, Appleby PN, Allen NE, Lindstrom S, Schumacher FR, Cox D, Hsing AW, Ma J, Severi G, Albanes D, Virtamo J, Boeing H, Bueno-de-Mesquita HB, Johansson M, Quirós JR, Riboli E, Siddiq A, Tjønneland A, Trichopoulos D, ...show more Tumino R, Gaziano JM, Giovannucci E, Hunter DJ, Kraft P, Stampfer MJ, Giles GG, Andriole GL, Berndt SI, Chanock SJ, Hayes RB, Key TJ
Am. J. Epidemiol. 2012 May; Volume 175 (Issue 9): Pages 926-35 PUBMED -
Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.
Gu F, Schumacher FR, Canzian F, Allen NE, Albanes D, Berg CD, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Buring JE, Chabbert-Buffet N, Chanock SJ, Clavel-Chapelon F, Dumeaux V, Gaziano JM, Giovannucci EL, Haiman CA, Hankinson SE, Hayes RB, Henderson BE, ...show more Hunter DJ, Hoover RN, Johansson M, Key TJ, Khaw KT, Kolonel LN, Lagiou P, Lee IM, LeMarchand L, Lund E, Ma J, Onland-Moret NC, Overvad K, Rodriguez L, Sacerdote C, Sánchez MJ, Stampfer MJ, Stattin P, Stram DO, Thomas G, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Virtamo J, Weinstein SJ, Willett WC, Yeager M, Zhang SM, Kaaks R, Riboli E, Ziegler RG, Kraft P
Cancer Epidemiol. Biomarkers Prev. 2010 Nov; Volume 19 (Issue 11): Pages 2877-87 PUBMED -
A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Lindström S, Ma J, Altshuler D, Giovannucci E, Riboli E, Albanes D, Allen NE, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Chanock SJ, Dunning AM, Feigelson HS, Gaziano JM, Haiman CA, Hayes RB, Henderson BE, Hunter DJ, Kaaks R, Kolonel LN, ...show more Le Marchand L, Martínez C, Overvad K, Siddiq A, Stampfer M, Stattin P, Stram DO, Thun MJ, Trichopoulos D, Tumino R, Virtamo J, Weinstein SJ, Yeager M, Kraft P, Freedman ML
J. Clin. Endocrinol. Metab. 2010 Sep; Volume 95 (Issue 9): Pages E121-7 PUBMED -
CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium.
Travis RC, Schumacher F, Hirschhorn JN, Kraft P, Allen NE, Albanes D, Berglund G, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Calle EE, Chanock S, Dunning AM, Hayes R, Feigelson HS, Gaziano JM, Giovannucci E, Haiman CA, Henderson BE, Kaaks R, ...show more Kolonel LN, Ma J, Rodriguez L, Riboli E, Stampfer M, Stram DO, Thun MJ, Tjønneland A, Trichopoulos D, Vineis P, Virtamo J, Le Marchand L, Hunter DJ
Cancer Epidemiol. Biomarkers Prev. 2009 Oct; Volume 18 (Issue 10): Pages 2734-44 PUBMED -
Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
Ahn J, Schumacher FR, Berndt SI, Pfeiffer R, Albanes D, Andriole GL, Ardanaz E, Boeing H, Bueno-de-Mesquita B, Chanock SJ, Clavel-Chapelon F, Diver WR, Feigelson HS, Gaziano JM, Giovannucci E, Haiman CA, Henderson BE, Hoover RN, Kolonel LN, Kraft P, ...show more Ma J, Le Marchand L, Overvad K, Palli D, Stattin P, Stampfer M, Stram DO, Thomas G, Thun MJ, Travis RC, Trichopoulos D, Virtamo J, Weinstein SJ, Yeager M, Kaaks R, Hunter DJ, Hayes RB
Hum. Mol. Genet. 2009 Oct; Volume 18 (Issue 19): Pages 3749-57 PUBMED -
Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial.
Schenk JM, Riboli E, Chatterjee N, Leitzmann MF, Ahn J, Albanes D, Reding DJ, Wang Y, Friesen MD, Hayes RB, Peters U
Cancer Epidemiol. Biomarkers Prev. 2009 Apr; Volume 18 (Issue 4): Pages 1227-31 PUBMED -
Sexually transmissible infections and prostate cancer risk.
Huang WY, Hayes R, Pfeiffer R, Viscidi RP, Lee FK, Wang YF, Reding D, Whitby D, Papp JR, Rabkin CS
Cancer Epidemiol. Biomarkers Prev. 2008 Sep; Volume 17 (Issue 9): Pages 2374-81 PUBMED -
Endogenous sex hormones and the risk of prostate cancer: a prospective study.
Weiss JM, Huang WY, Rinaldi S, Fears TR, Chatterjee N, Hsing AW, Crawford ED, Andriole GL, Kaaks R, Hayes RB
Int. J. Cancer. 2008 May; Volume 122 (Issue 10): Pages 2345-50 PUBMED -
Serum selenium and risk of prostate cancer-a nested case-control study.
Peters U, Foster CB, Chatterjee N, Schatzkin A, Reding D, Andriole GL, Crawford ED, Sturup S, Chanock SJ, Hayes RB
Am. J. Clin. Nutr. 2007 Jan; Volume 85 (Issue 1): Pages 209-17 PUBMED