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Principal Investigator
Neil Caporaso
Position Title
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Aug 12, 2013
One-carbon metabolism and risk of lung cancer in a multi-cohort consortium
Aim of study and expected outcomes
Significance of project

Specific aims
1. To accurately measure the association between circulating levels of vitamin B6, methionine and folate, as well as other B-vitamins and related compounds (including homocysteine, vitamin B2 and vitamin B12) and subsequent lung cancer risk
2. To provide accurate risk estimates for groups stratified by B-vitamin levels and smoking status (in particular in never and ex-smokers)
3. To analyze the effect of having low levels of multiple B-vitamins and related compounds, and test the hypothesis that their effects are, at least partially, independent
4. To calculate the within-person variation of B-vitamins and adjust results for regression dilution that occurs because of this variation
5. To analyze SNPs known to be associated with B-vitamin levels based on recent genome-wide studies, including additional case-control studies from the ILCCO consortium, in order to obtain independent and robust evidence of a causal effect of these B-vitamins
Participating cohorts
1. To provide 500 µL plasma or serum for prospectively collected lung cancer cases and controls (individually matched 1:1)
2. To provide repeated plasma or serum samples for a subset of included controls
3. To provide detailed questionnaire data on risk factors including smoking variables, demographic, and dietary variables
4. To provide DNA (500 ng) in order to analyze specific single nucleotide polymorphisms known to influence factors of one-carbon metabolism
5. To provide follow-up data on vital status and cause of death



Related Publications
  • Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
    Larose TL, Guida F, Fanidi A, Langhammer A, Kveem K, Stevens VL, Jacobs EJ, Smith-Warner SA, Giovannucci E, Albanes D, Weinstein SJ, Freedman ND, Prentice R, Pettinger M, Thomson CA, Cai Q, Wu J, Blot WJ, Arslan AA, Zeleniuch-Jacquotte A, more Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Hodge AM, Giles GG, Severi G, Johansson M, Grankvist K, Wang R, Yuan JM, Gao YT, Koh WP, Shu XO, Zheng W, Xiang YB, Li H, Lan Q, Visvanathan K, Hoffman Bolton J, Ueland PM, Midttun Ø, Caporaso N, Purdue M, Sesso HD, Buring JE, Lee IM, Gaziano JM, Manjer J, Brunnström H, Brennan P, Johansson M
    Int J Epidemiol. 2018 Jun PUBMED
  • No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3).
    Muller DC, Hodge AM, Fanidi A, Albanes D, Mai XM, Shu XO, Weinstein SJ, Larose TL, Zhang X, Han J, Stampfer MJ, Smith-Warner SA, Ma J, Gaziano JM, Sesso HD, Stevens VL, McCullough ML, Layne TM, Prentice R, Pettinger M, more Thomson CA, Zheng W, Gao YT, Rothman N, Xiang YB, Cai H, Wang R, Yuan JM, Koh WP, Butler LM, Cai Q, Blot WJ, Wu J, Ueland PM, Midttun Ø, Langhammer A, Hveem K, Johansson M, Hultdin J, Grankvist K, Arslan AA, Le Marchand L, Severi G, Johansson M, Brennan P
    Ann. Oncol. 2018 Jun 1; Volume 29 (Issue 6): Pages 1468-1475 PUBMED
  • Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3).
    Fanidi A, Muller DC, Yuan JM, Stevens VL, Weinstein SJ, Albanes D, Prentice R, Thomsen CA, Pettinger M, Cai Q, Blot WJ, Wu J, Arslan AA, Zeleniuch-Jacquotte A, McCullough ML, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Han J, more Stampfer MJ, Smith-Warner SA, Giovannucci E, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Krokstad S, Næss M, Wang R, Gao YT, Butler LM, Koh WP, Shu XO, Xiang YB, Li H, Zheng W, Lan Q, Visvanathan K, Bolton JH, Ueland PM, Midttun Ø, Ulvik A, Caporaso NE, Purdue M, Ziegler RG, Freedman ND, Buring JE, Lee IM, Sesso HD, Gaziano JM, Manjer J, Ericson U, Relton C, Brennan P, Johansson M
    J. Natl. Cancer Inst. 2018 Jan; Volume 110 (Issue 1) PUBMED