No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3).
About this Publication
Title
No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3).
Pubmed ID
29617726
(View this publication on the PubMed website)
Digital Object Identifier
Publication
Ann. Oncol. 2018 Jun 1; Volume 29 (Issue 6): Pages 1468-1475
Authors
Muller DC, Hodge AM, Fanidi A, Albanes D, Mai XM, Shu XO, Weinstein SJ, Larose TL, Zhang X, Han J, Stampfer MJ, Smith-Warner SA, Ma J, Gaziano JM, Sesso HD, Stevens VL, McCullough ML, Layne TM, Prentice R, Pettinger M, ...show more Thomson CA, Zheng W, Gao YT, Rothman N, Xiang YB, Cai H, Wang R, Yuan JM, Koh WP, Butler LM, Cai Q, Blot WJ, Wu J, Ueland PM, Midttun Ø, Langhammer A, Hveem K, Johansson M, Hultdin J, Grankvist K, Arslan AA, Le Marchand L, Severi G, Johansson M, Brennan P
Affiliations
- Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France; Department of Epidemiology and Biostatistics, Imperial College London, London, UK. Electronic address: david.muller@imperial.ac.uk.
- Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Australia.
- Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, USA.
- Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA.
- Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston; Harvard Medical School, Boston, USA.
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, USA; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, USA.
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston; Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.
- Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Division of Boston VA Medical Center, Boston, USA.
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA.
- Division of Epidemiology Research Program, American Cancer Society, Atlanta, USA.
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA.
- Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, USA.
- Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai.
- State Key Laboratory of Oncogene and Related Genes, Shanghai Jiaotong University School of Medicine, Shanghai, China; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA.
- UPMC Hillman Cancer Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA.
- UPMC Hillman Cancer Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA.
- Duke-NUS Graduate Medical School Singapore, Singapore, Singapore.
- Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, USA.
- Laboratory of Clinical Biochemistry, Department of Clinical Science, University of Bergen, Bergen, Norway; Haukeland University Hospital, Bergen, Norway.
- Bevital AS, Bergen, Norway.
- Department of Public Health and Nursing, HUNT Research Centre, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
- Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Public Health and Nursing, HUNT Research Centre, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
- Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
- Department of Obstetrics and Gynecology, New York University School of Medicine, New York, USA; Department of Population Health and Environmental Medicine, New York University School of Medicine, New York, USA.
- Department of Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA.
- Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Australia; Italian Institute for Genomic Medicine (IIGM), Torino, Italy; Centre de Recherche en Epidemiologie et Santé des Populations (CESP) UMR1018 Inserm, Facultés de Médicine, Université Paris-Saclay, Villejuif, France.
- Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
- Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France. Electronic address: gep@iarc.fr.
Abstract
BACKGROUND: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3).
PATIENTS AND METHODS: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables.
RESULTS: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology.
CONCLUSION: This study did not support an association between vitamin D concentrations and lung cancer risk.
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