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Genetically Determined Height and Risk of Non-hodgkin Lymphoma.

About this Publication
Title
Genetically Determined Height and Risk of Non-hodgkin Lymphoma.
Pubmed ID
32064237 (View this publication on the PubMed website)
Digital Object Identifier
Publication
Front Oncol. 2019; Volume 9: Pages 1539
Authors
Moore A, Kane E, Wang Z, Panagiotou OA, Teras LR, Monnereau A, Wong Doo N, Machiela MJ, Skibola CF, Slager SL, Salles G, Camp NJ, Bracci PM, Nieters A, Vermeulen RCH, Vijai J, Smedby KE, Zhang Y, Vajdic CM, Cozen W, ...show more Spinelli JJ, Hjalgrim H, Giles GG, Link BK, Clavel J, Arslan AA, Purdue MP, Tinker LF, Albanes D, Ferri GM, Habermann TM, Adami HO, Becker N, Benavente Y, Bisanzi S, Boffetta P, Brennan P, Brooks-Wilson AR, Canzian F, Conde L, Cox DG, Curtin K, Foretova L, Gapstur SM, Ghesquières H, Glenn M, Glimelius B, Jackson RD, Lan Q, Liebow M, Maynadie M, McKay J, Melbye M, Miligi L, Milne RL, Molina TJ, Morton LM, North KE, Offit K, Padoan M, Patel AV, Piro S, Ravichandran V, Riboli E, de Sanjose S, Severson RK, Southey MC, Staines A, Stewart C, Travis RC, Weiderpass E, Weinstein S, Zheng T, Chanock SJ, Chatterjee N, Rothman N, Birmann BM, Cerhan JR, Berndt SI
Affiliations
  • Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
  • Department of Health Sciences, University of York, York, United Kingdom.
  • Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, United States.
  • Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, United States.
  • Epidemiology Research Program, American Cancer Society, Atlanta, GA, United States.
  • Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.
  • Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
  • Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, United States.
  • Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States.
  • Department of Hematology, Hospices Civils de Lyon, Lyon, France.
...show more
  • Division of Hematology and Hematologic Malignancies, Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United States.
  • Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
  • Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg im Breisgau, Germany.
  • Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
  • Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
  • Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
  • Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, United States.
  • Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia.
  • Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
  • Cancer Control Research, BC Cancer, Vancouver, BC, Canada.
  • Division of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States.
  • Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, United States.
  • Ontario Health Study, Toronto, ON, Canada.
  • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
  • Interdisciplinary Department of Medicine, University of Bari, Bari, Italy.
  • Division of General Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United States.
  • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Regional Cancer Prevention Laboratory, Oncological Network, Prevention and Research Institute (ISPRO), Florence, Italy.
  • The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • International Agency for Research on Cancer (IARC), Lyon, France.
  • Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
  • Genomic Epidemiology Group, German Cancer Research Center, Heidelberg, Germany.
  • Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, United Kingdom.
  • INSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France.
  • Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States.
  • Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czechia.
  • Equipe Experimental and Clinical Models of Lymphomagenesis, Cancer Research Center of Lyon, Institut National de Santé et de la Recherche Médicale UMR1052 Pierre Benite, Lyon, France.
  • Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States.
  • Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, United States.
  • INSERM U1231, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, France.
  • Environmental and Occupational Epidemiology Unit, Oncological Network, Prevention and Research Institute (ISPRO), Florence, Italy.
  • Department of Pathology, AP-HP, Necker Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  • CPO-Piemonte and Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Piemonte Orientale, Novara, Italy.
  • School of Public Health, Imperial College London, London, United Kingdom.
  • Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, United States.
  • Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, VIC, Australia.
  • School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.
  • Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
  • International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Department of Epidemiology, Brown School of Public Health, Providence, RI, United States.
  • Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Abstract

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

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