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Tobacco Smoking and Risk of Second Primary Lung Cancer.

About this Publication
Title
Tobacco Smoking and Risk of Second Primary Lung Cancer.
Pubmed ID
33722709 (View this publication on the PubMed website)
Digital Object Identifier
Publication
J Thorac Oncol. 2021 Mar 12
Authors
Aredo JV, Luo SJ, Gardner RM, Sanyal N, Choi E, Hickey TP, Riley TL, Huang WY, Kurian AW, Leung AN, Wilkens LR, Robbins HA, Riboli E, Kaaks R, Tjønneland A, Vermeulen RCH, Panico S, Le Marchand L, Amos CI, Hung RJ, ...show more Freedman ND, Johansson M, Cheng I, Wakelee HA, Han SS
Affiliations
  • Stanford University School of Medicine, Stanford, California.
  • Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, California.
  • Information Management Systems, Rockville, Maryland.
  • Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland.
  • Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California; Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.
  • Department of Radiology, Stanford University School of Medicine, Stanford, California.
  • Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • International Agency for Research on Cancer, Lyon, France.
  • Epidemiology and Prevention, School of Public Health, Imperial College London, London, United Kingdom.
  • Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Center for Lung Research, Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.
...show more
  • Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Division Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
  • Department of Medicine, Baylor College of Medicine, Houston, Texas.
  • Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Department of Epidemiology and Biostatistics, University of California, San Francisco, California.
  • Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California.
  • Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, California; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California. Electronic address: summer.han@stanford.edu.
Abstract

INTRODUCTION: Lung cancer survivors are at high risk of a second primary lung cancer (SPLC). However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. We examined risk factors for SPLC across multiple epidemiologic cohorts and assessed the impact of smoking cessation on reducing SPLC risk.

METHODS: We analyzed data from 7,059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. Cause-specific proportional hazards models estimated SPLC risk. We conducted validation studies using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, N=3,423 IPLC cases) and European Prospective Investigation into Cancer and Nutrition (EPIC, N=4,731 IPLC cases) cohorts and pooled the SPLC risk estimates using random effects meta-analysis.

RESULTS: Overall, 163 (2.3%) MEC cases developed a SPLC. Smoking pack-years (HR 1.18 per 10 pack-years; P<0.001) and smoking intensity (HR 1.30 per 10 cigarettes per day (CPD); P<0.001) were significantly associated with increased SPLC risk. Individuals who met the 2013 U.S. Preventive Services Task Force's (USPSTF) screening criteria at IPLC diagnosis also had an increased SPLC risk (HR 1.92; P<0.001). Validation studies with PLCO and EPIC showed consistent results. Meta-analysis yielded pooled HRs of 1.16 per 10 pack-years (Pmeta<0.001), 1.25 per 10 CPD (Pmeta<0.001), and 1.99 (Pmeta<0.001) for meeting the USPSTF criteria. In MEC, smoking cessation after IPLC diagnosis was associated with an 83% reduction in SPLC risk (HR 0.17; P<0.001).

CONCLUSIONS: Tobacco smoking is a risk factor for SPLC. Smoking cessation after IPLC diagnosis may reduce the risk of SPLC. Additional strategies for SPLC surveillance and screening are warranted.

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