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Optimal endoscopy screening and surveillance intervals for colorectal cancer

Principal Investigator
Name
Xin Zhou
Degrees
PhD
Institution
Harvard University
Position Title
Postdoc Fellow
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-174
Initial CDAS Request Approval
Nov 2, 2015
Title
Optimal endoscopy screening and surveillance intervals for colorectal cancer
Summary
Screening for colorectal cancer (CRC) in asymptomatic patients can reduce the incidence and mortality of CRC. Current guidelines for colonoscopy surveillance recommend repeated screening at an interval of ten years for the low-risk population, and at an interval of 3-5 years for high-risk population. We endeavor to develop a decision strategy to determine an optimal personalized interval for endoscopy screening and surveillance. The decision may take patient factors (such as age, gender, CRC family history, lifestyle) and polyps factors (such as type, number, size) into consideration, and may perform a cost-effectiveness analysis.
Aims

We would like to utilize PLCO trial data for the following aims. The outcome will be incidence and mortality of CRC.

1. We will generate a risk score incorporating patient factors and polyps factors.

2. We will develop a personalized strategy to determine an optimal screening and surveillance interval.

REFERENCES
1. Nishihara, R, Wu, K, Lochhead, P, et al. Long-term colorectal-cancer incidence and mortality after lower endoscopy. New England Journal of Medicine 2013; 369: 1095-1105.

2. Lieberman, DA, Rex, DK, Winawer, SJ, Giardiello, FM, Johnson, DA, Levin, TR, Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on colorectal cancer. Gastroenterology 2012; 143: 844-857.

Collaborators

Dr. Donna Spiegelman
Dr. Yin Cao
Dr. Reiko Nishihara