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Validation study of associations of medical conditions with subtypes of non-Hodgkin lymphoma

Principal Investigator
Name
Eric Engels
Degrees
MD MPH
Institution
NCI
Position Title
Senior investigator
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-138
Initial CDAS Request Approval
Mar 19, 2015
Title
Validation study of associations of medical conditions with subtypes of non-Hodgkin lymphoma
Summary
Some medical conditions may affect risk of developing non-Hodgkin lymphoma (NHL) by affecting the immune system or through other unknown mechanisms, and these effects likely vary across histologically defined NHL subtypes. In a recent analysis of the SEER-Medicare dataset, we observed inverse associations between hypertension and chronic lymphocytic leukemia (CLL), chronic bronchitis and diffuse large B cell lymphoma (DLBCL), and stroke and several NHL subtypes; and a positive association between diabetes and DLBCL (unpublished data). These associations are partly based on the assessment of claims data. We request PLCO data to validate our findings using an independent dataset. We propose a cohort analysis in which we will assess associations of these medical conditions, reported on the baseline questionnaire, with subsequent risk of developing specified NHL subtypes. We will also evaluate emphysema as a risk factor, since it is closely related to chronic bronchitis as a type of COPD. NHL subtypes (DLBCL, CLL, and several other common subtypes) will be defined using ICD-O morphology codes. We will utilize Cox regression for the statistical analyses. We anticipate that these results, whether or not they confirm our SEER-Medicare analyses, will be included in the published article along with those data, and that these results will help inform an etiologic understanding of NHL.
Aims

Assess associations of medical conditions (chronic bronchitis, emphysema, hypertension, diabetes, stroke) with risk of developing subtypes of NHL.

Collaborators

Lindsay Morton, National Cancer Institute
Ruth Pfeiffer, National Cancer Institute