Cause of death in the NLST and PLCO: comparison of death certificates and endpoint adjudication

Principal Investigator

Name
Pamela Marcus

Degrees
PhD

Institution
NCI

Position Title
Epidemiologist

Email
marcusp@mail.nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-117

Initial CDAS Request Approval
Nov 10, 2014

Title
Cause of death in the NLST and PLCO: comparison of death certificates and endpoint adjudication

Summary
We will explore measures of agreement (percent agreement, kappa, sensitivity, specificity, PPV, NPV) in cause of death between death certificates and endpoint adjudication in PLCO. We will also be doing this with NLST data (see NLST CDAS request).

Aims

1. Look at agreement with regard to cause of death between death certificate cause of death and death review cause of death. Explore by study arm in addition to independent of study arm.
Look at this for all P,L,C and O deaths separately and together.
2. Compare final interim analyses using DC P,L,C,O cause of death and P,L,C,O death review cause of death as outcomes.
3. Look at patterns of change among those participants whose cause of death changed from P,L,C,O cancer to something else after death review. Look at patterns of change among those participants who did not have P,L,C,O cancer listed as cause of death on their death certificate but were assigned P,L,C,O cancer after death review

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Collaborators

Tony Miller (U of Toronto)
Ilana Gareen (Brown)
Phil Prorok (NCI)
Jennifer Rosenbaum (Westat)
Nancy Payte (Westat)
Paul Doria-Rose (NCI)
Kristen Keating (Westat)
Brenda Brewer (Westat)
Heather Rozjabek (Drexel)
Josh Rathmell (IMS)
Kathy Clingan (Westat)
Tom Riley (IMS)
Susan Yurgalevitch (Westat)
Amy Miller (Westat)