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Genome-Wide Predictors of Survival in Colorectal Cancer

Principal Investigator

Name
Polly Newcomb

Degrees
PhD, MPH

Institution
Fred Hutchinson Cancer Center

Position Title
Member

Email
pnewcomb@fhcrc.org

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-101

Initial CDAS Request Approval
Oct 7, 2014

Title
Genome-Wide Predictors of Survival in Colorectal Cancer

Summary
Worldwide, approximately 1 million people are diagnosed with and 500,000 die from colorectal cancer (CRC) each year. Although much is known about what factors are associated with risk of developing CRC, relatively little is known about factors associated with survival after CRC diagnosis. There is increasing evidence that CRC survival has a genetic component. Improved understanding of the genetic basis underlying CRC survival will provide insights into mechanisms of cancer progression and provide potential prognostic markers. Additionally, incorporating environmental/ lifestyle and treatment data will allow for more refined analyses and more confidence of the specific effects of germline variants, environmental exposures, and treatment on CRC survival.

Aims

For this project, we aim to identify single nucleotide polymorphisms (SNPs) or regions associated with survival after CRC diagnosis and associated with treatment toxicity. We will utilize the identified associated variants to improve prognostic models by included genetic data to existing models. We will also explore the relationship between genetic variants, environmental exposures, and CRC survival. We will integrate tumor characteristic data, as available, into these analyses as able to better illuminate these relationships. To undertake this, we propose utilizing PLCO GWAS and sequence data, environmental data, treatment data, tumor characteristics data, and survival/outcome data. Data may be used in conjunction with other studies’ data from the Genetics & Epidemiology of Colorectal Cancer Consortium (GECCO) and from the Molecular Correlates of Outcomes in Clinical Trials project (R01-CA176272).

Collaborators

Ulrike Peters, Fred Hutchinson Cancer Research Center

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