Thyroid Cancer and NSAIDs

Principal Investigator

Name
Jigarkumar Patel

Degrees
MD

Institution
NCI, DCP, GOCRG

Position Title
Research Surgical Collaborator

Email
jigar.patel@nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-69

Initial CDAS Request Approval
Mar 12, 2014

Title
Thyroid Cancer and NSAIDs

Summary
COX-2 expression has been demonstrated in multiple thryoid diseases in both animal and human tissue models. Additionally, COX-2 overexpression has been demonstrated in folliclar carcinoma but not in normal thyroid tissue.

NSAIDs have been extensively studied in chemoprevention in colorectal adenomas and carcinoma, along with multiple other sites like the esophagus and stomach, possibly by the same mechanism.

This effect has yet to be demonstrated from a cohort population in thyroid cancer.

Aims

To evaluate for a relationship between thyroid malignancy and NSAID use from a cohort study, which could further strengthen the use of NSAIDs as a chemopreventive adjunct.

Collaborators

Dr. Asad Umar, NCI, DCP
Dr. Luz Rodriguez, NCI, DCP