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Thyroid Cancer and NSAIDs

Principal Investigator
Name
Jigarkumar Patel
Degrees
MD
Institution
NCI, DCP, GOCRG
Position Title
Research Surgical Collaborator
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-69
Initial CDAS Request Approval
Mar 12, 2014
Title
Thyroid Cancer and NSAIDs
Summary
COX-2 expression has been demonstrated in multiple thryoid diseases in both animal and human tissue models. Additionally, COX-2 overexpression has been demonstrated in folliclar carcinoma but not in normal thyroid tissue.

NSAIDs have been extensively studied in chemoprevention in colorectal adenomas and carcinoma, along with multiple other sites like the esophagus and stomach, possibly by the same mechanism.

This effect has yet to be demonstrated from a cohort population in thyroid cancer.
Aims

To evaluate for a relationship between thyroid malignancy and NSAID use from a cohort study, which could further strengthen the use of NSAIDs as a chemopreventive adjunct.

Collaborators

Dr. Asad Umar, NCI, DCP
Dr. Luz Rodriguez, NCI, DCP