Effect of Stage and Grade on Colorectal Cancer Mortality

Principal Investigator

Name
Paul Pinsky

Institution
National Institutes of Health

Position Title
Chief, EDRG

Email
pp4f@nih.gov

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-2028

Initial CDAS Request Approval
Feb 26, 2026

Title
Effect of Stage and Grade on Colorectal Cancer Mortality

Summary
To examine the effect of stage, grade and mode of detection on colorectal cancer mortality and survival.
We will classify each case based on their tumor grade - well differentiated, moderately differntiated, poorly differentiated and undifferentiated. We will look at TNM stage, I, II, III and IV. We will look at mode of detection - screening, surveillance, symptoms
We will look at survival at different time points - 5 years, 10 years, 15 years.
We will use Kaplan Meier curves and life tables analysis. We will examine the effect of prevention versus early detection on mortality reduction, estimating the percentage effect of each.

Aims

To examine the effect of stage, grade and mode of detection on colorectal cancer mortality and survival.
We will classify each case based on their tumor grade - well differentiated, moderately differntiated, poorly differentiated and undifferentiated. We will look at TNM stage, I, II, III and IV. We will look at mode of detection - screening, surveillance, symptoms
We will look at survival at different time points - 5 years, 10 years, 15 years.
We will use Kaplan Meier curves and life tables analysis. We will examine
the effect of prevention versus early detection on mortality reduction, estimating the percentage of each effect.

Collaborators

Paul Pinsky National Institutes of Health