Smoking and Lung Cancer in PLCO and NLST
Principal Investigator
Name
Rayjean Hung
Degrees
PhD
Institution
Sinai Health System
Position Title
Head and Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-42
Initial CDAS Request Approval
Jul 25, 2013
Title
Smoking and Lung Cancer in PLCO and NLST
Summary
The Lung U!9 (NIH U19 CA148127-01) and Genetic Epidemiology Branch investigators propose to look at PLCO data to examine the joint effects of smoking and genetic exposures on lung cancer in a range of populations. We intend to compare allele frequencies and magnitude of disease risk for a variety of variants and smoking behaviors. Data will be examined in PLCO, as well as other population-based cohorts such as ACS, ATBC, Caret, and the Nurses Health Study.
We will consider smoking but also take into account key covariates such as age, family history and COPD. We will also conduct specific analyses in controls to look at more detailed smoking behaviors, and to construct and validate risk models that incorporate the effects of smoking and other environmental factors.
We will consider smoking but also take into account key covariates such as age, family history and COPD. We will also conduct specific analyses in controls to look at more detailed smoking behaviors, and to construct and validate risk models that incorporate the effects of smoking and other environmental factors.
Aims
To compare lung cancer risk factors across PLCO and compare the findings to other population-based cohorts.
To compare heterogeneity of effects for key lung cancer risk variants by subject and disease characteristics.
To examine lung cancer risk models incorporating genetic and environmental factors.
Collaborators
Dr. Fangyi Gu
Dr. loic LeMarchaud
Dr. rayjean hung