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Assessment of Smoking Patterns and Risk Factors Associated with Lung Cancer Incidence: A Secondary Analysis of the PLCO Dataset

Principal Investigator
Name
Dr. Uttam Kumar Majumder
Degrees
Ph.D.
Institution
Khulna University
Position Title
Professor of Statistics Discipline khulna University
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1899
Initial CDAS Request Approval
Jul 11, 2025
Title
Assessment of Smoking Patterns and Risk Factors Associated with Lung Cancer Incidence: A Secondary Analysis of the PLCO Dataset
Summary
This project aims to investigate the association between smoking behaviors and the incidence of lung cancer utilizing data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. The study will examine smoking status (never, former, current), intensity (cigarettes per day), and duration (years smoked) as primary exposures, while accounting for demographic and clinical covariates such as age, sex, family history of cancer, and comorbidities. Stratified analyses will be performed to assess differences across various smoking subgroups. The findings are expected to contribute to a better understanding of modifiable risk factors for lung cancer and support the development of targeted public health interventions. This secondary analysis will leverage large-scale epidemiological data to generate evidence relevant to cancer prevention strategies both in the United States and globally.
Aims

To examine the association between smoking status (never, former, current) and the incidence of lung cancer among participants of the PLCO Trial.

To evaluate the impact of smoking intensity (cigarettes per day) and smoking duration (years smoked) on lung cancer risk.

To investigate demographic and behavioral factors (e.g., age, sex, family history, comorbidities) that may modify the association between smoking and lung cancer.

To conduct stratified analyses to explore differences in lung cancer incidence across smoking subgroups (e.g., heavy vs. light smokers).

To contribute to the scientific understanding of modifiable risk factors for lung cancer, informing future public health interventions.

Collaborators

Goffar Hossain Fahim, Khulna University
Sish Ahammed Sozol, Khulna University