Genome-Wide Association Study of Acute Myeloid Leukemia in Genomic Studies in Blood and Marrow Transplantation
In this study, we will conduct GWAS on the etiology of AML in a large sample of (nearly 11,000) patients diagnosed with AML undergoing hematopoietic cell transplantation. Donor and recipient samples were collected by the Center for International Blood and Marrow Transplantation Research (CIBMTR) and SNP arrays were genotyped at NCI/CGR on the GSA array. Demographics and disease characteristics were also collected by the CIBMTR. Besides eligible transplant donors, controls will be selected from PLCO participants with SNP data also assayed on the GSA array.
The aim of this project is to identify common variants conferring genetic susceptibility to AML. The primary analysis will be conducted on the full sample. Secondary analyses will be stratified by key patient and/or disease characteristics to identify potential heterogeneity across more homogenous subgroups with respect to disease stage.
Shahinaz Gadalla, Peter Kraft, Leila Abar, Xueyao Wu