Alcohol Intake and Prostate Cancer Mortality
Principal Investigator
Name
Yan Ding
Degrees
Ph.D.
Institution
City of Hope
Position Title
Assistant Research Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-30
Initial CDAS Request Approval
May 2, 2013
Title
Alcohol Intake and Prostate Cancer Mortality
Summary
Alcohol is a well-known carcinogen to human with target sites of oral cavity, pharynx, esophagus, larynx, breast, liver, and colon. Less certain is the role of alcohol consumption on prostate cancer incidence and mortality. Higher-frequency drinking has been associated with increased risk of mortality from prostate cancer in a prospective study, National Health Interview Survey, in the US population. We recently detected association of daily amount of alcohol intake with prostate cancer-specific mortality (PCSM, Hazard Ratio [HR] = 1.15, p = 0.0039) in the prostate cancer cohort of Cancer Genetic Markers and Susceptibility (CGEMS). The association was most significant for patients who received prostatectomy as the first course of treatment (HR = 1.27, p < 0.0001) after adjusting for disease characteristics and other variables. We propose to confirm the association of alcohol intake with PCSM using the full cohort of prostate cancer in the PLCO trial. We will also examine heterogeneity of the alcohol effect among treatment groups, among sources of alcohol, and among genotypes of SNPs in FHIT associated with PCSM using Cox models.
Aims
The Specific Aims are (1) to evaluate the association in 5 treatment categories: prostatectomy, radiation, hormonal, radiation plus hormonal, and treatment without curative intent. The hypothesis is that effect of alcohol on PCSM is specific to treatment; (2) to evaluate the association with different categories of alcohol: wine, beer, and liquor. We’ll test the hypothesis that components in wine extenuate the effect of alcohol on PCSM; (3) to test interaction between alcohol and SNPs in FHIT for PCSM. The hypothesis is that alcohol modifies risk of PCSM through SNPs in FHIT.