Energy Balance, Mortality and Healthy Survival (Updated)
This current application is a reactivation of an earlier approved proposal submitted by Dr. Bradley Wilcox (<a href="/cdas/plco/pubs_projects/project/150/">2007-054</a>). We request updated data to increase study power. We have had discussions with IMS (Tom Riley's team) and they are familiar with the required data elements. Dr. Wilcox is still actively involved in this project. Dr. Tammemagi has been now entered as this projects PI, because he will be controlling the data, carrying out the statistical analysis and leading writing of the manuscript. The current project also overlaps with another PLCO ancillary study lead by Dr. Tammemagi: Socioeconomic status, behaviours, exposures, and health outcomes.
Note: Prior work related to this project was done in <a href="/cdas/plco/pubs_projects/project/150/">2007-054</a>.
We will study the independent and joint effects of energy intake, current BMI, and recent physical activity on mortality risk (including cause-specific mortality for CHD, cancer, stroke) and risk for healthy survival in the screening arm of the PLCO Trial. Energy intake and physical activity will be estimated with the DQX, which was administered at baseline to subjects assigned to screening. 2) We will also use the DHQ, administered ~ four years after baseline to subjects assigned to both arms of the PLCO Trial, to estimate energy intake. This will allow us to investigate the independent and joint effects of energy intake, current BMI, and physical activity on mortality, cause-specific mortality and healthy survival. 3) We will investigate the independent and joint effects of current BMI, BMI at age 50, BMI at age 20, adult weight gain, recent weight gain, and height on these phenotypes in both arms of the Trial. 4) We will also stratify the data by smoking status to assess whether effects of energy intake are stronger in never smokers.
Dr. Bradley Wilcox (Pacific Health Research Institute)
Vicki Shambaugh (Pacific Health Research & Education Institute)