Effect of bilater salpingo-oophorectomy on morbidity and mortality
Principal Investigator
Name
Amanda Black
Institution
NCI, DCEG, EBP
Position Title
Staff Scientist
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-19
Initial CDAS Request Approval
Mar 14, 2013
Title
Effect of bilater salpingo-oophorectomy on morbidity and mortality
Summary
Each year in the US over 600,000 women undergo hysterectomy for benign disease. Most of these procedures are performed in peri- and post-menopausal women in whom coincident bilateral salpingo-oopherectomy (BSO) may be considered in order to prevent ovarian cancer. BSO is a proven prevention strategy even among women at high genetic risk but is associated with complications including symptoms of hypoestrogenemia and possibly increased risk for a number of diseases including cardiovascular disease (CVD), osteoporosis and cancer; the severity of at least some complications appears to be reduced by use of hormone replacement therapy (HRT) following BSO. A recent decision model suggests that BSO prior to age 65 increases mortality overall; however this analysis is based on assumptions reported from a single observational study that has significant limitations. Furthermore these analyses do not take into account an individual woman’s baseline disease risk. Currently there remains a great deal of uncertainty about how best to interpret the available information and to inform decisions regarding BSO for an individual woman.
Aims
To develop an information tool that will provide women and health providers with individualized, quantitative information about the relative risks and benefits of undergoing BSO at the time of hysterectomy for benign gynecological disease.
Collaborators
Charles Drescher, Mark Sherman, Ruth Pfeiffer, Gretchen Gierach