Incorporating blood biomarker with self reported exercise in PLCO cohort
Principal Investigator
Name
Ehsan Irajizad
Degrees
Ph.D.,
Institution
University of Texas MD Anderson Cancer Center
Position Title
Assistant Professor
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1710
Initial CDAS Request Approval
Oct 17, 2024
Title
Incorporating blood biomarker with self reported exercise in PLCO cohort
Summary
In our prior work, we leveraged plasma samples from Prostate, Lung, Colorectal, and Ovarian Trial (PLCO) to validate blood-based biomarker panels associated with 6-year risks of developing various forms of cancers including lung, breast, pancreatic, and ovarian cancers. One of the key components of the PLCO cohort is the comprehensive collection of patient characteristics, including smoking behavior and other self-reported factors like exercise habits.
In a recent study, Dr. Lee Jones and colleagues utilized the PLCO dataset to demonstrate that self-reported exercise was a significant predictor of the risk for various types of cancer. Specifically, for individual cancers, exercisers had a 26% lower risk of head and neck cancer, 20% lower risk of lung cancer, and 11% lower risk of breast cancer compared with non-exercisers.
With a view toward future intervention trials, we believe that integrating blood biomarkers with Dr. Jones' findings on exercise and its association with cancer risk would improve the identification of individuals at risk and enhance recommendations for screening and intervention.
To do this, we request approval to receive quantification of exercise dose from Dr. Jones (Dr. Jones is fully supportive and will be a co-author on any manuscripts that may result from the proposed analyses) to perform these ancillary analyses as a logical extension of our currently approved projects.
In a recent study, Dr. Lee Jones and colleagues utilized the PLCO dataset to demonstrate that self-reported exercise was a significant predictor of the risk for various types of cancer. Specifically, for individual cancers, exercisers had a 26% lower risk of head and neck cancer, 20% lower risk of lung cancer, and 11% lower risk of breast cancer compared with non-exercisers.
With a view toward future intervention trials, we believe that integrating blood biomarkers with Dr. Jones' findings on exercise and its association with cancer risk would improve the identification of individuals at risk and enhance recommendations for screening and intervention.
To do this, we request approval to receive quantification of exercise dose from Dr. Jones (Dr. Jones is fully supportive and will be a co-author on any manuscripts that may result from the proposed analyses) to perform these ancillary analyses as a logical extension of our currently approved projects.
Aims
1- Incorporating the blood information with self-reported exercise information to improve cancer risk assessment
2- Incorporating the blood information with second hand smoking information to improve cancer risk assessment
Collaborators
Dr. Johannes Fahrmann (MD Anderson Cancer Center)
Dr. Lee Jones (Memorial Sloan Kettering Cancer Center)