Demographic, lifestyle, reproductive, and hormonal factors, medical history, and medication use in relation to glioma in the PLCO study
This study is suitable for the PLCO cohort because detailed information on demographic characteristics, anthropometric measures, family history of cancer, reproductive factors, smoking history, and personal medical history was collected from study participants at baseline. In particular, PLCO collected data on several medical conditions, benign reproductive conditions, and reproductive surgical procedures. Since much of the etiology of glioma is unknown, this research may help to provide etiological clues and aid in identifying highly susceptible populations for cancer screenings (e.g., persons with benign reproductive conditions).
Using baseline questionnaire data, we plan to investigate the associations between anthropometric measures (height, weight), occupation, smoking history, family history of cancer, aspirin or ibuprofen use, prior diagnosis of medical conditions (hypertension, coronary heart disease, stroke, emphysema, chronic bronchitis, diabetes, colorectal polyp, ulcerative colitis, Crohn’s Disease, familial polyposis, arthritis, osteoporosis, Gardner’s Syndrome, hepatitis, cirrhosis, diverticulitis/diverticulosis, and gall bladder stones or inflammation), personal medical history of reproductive conditions for women (medical history of benign or fibrocystic breast disease, benign ovarian tumor or cyst, endometriosis, uterine fibroid tumors ) and men (problem with prostate, inflamed prostate/prostatitis, syphilis, gonorrhea), personal history of cancer, reproductive factors for women (age at menarche, age at menopause, type of menopause, age at first pregnancy, age at first birth, parity, number of pregnancies, results of pregnancies, number of live births, oral contraceptive use), surgical procedures for women (tubal ligation, hysterectomy, removal of ovaries, hormonal therapy use) and men (biopsy, transurethral resection of the prostate, prostatectomy, prostate surgery, vasectomy), diagnostic utilization among women (chest x-ray, mammogram, pap smear, pelvic examination, ultrasound, blood test for ovarian cancer, stool test, colonoscopy) and men(chest x-ray, digital rectal examination of the prostate, blood test for prostate cancer, stool test, colonoscopy) and glioma risk.
Cari M. Kitahara