Plant-based diets and microbiome
Principal Investigator
Name
Rachael Stolzenberg-Solomon
Degrees
PH.D, R.D., M.P.H.
Institution
DCEG/NCI
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1678
Initial CDAS Request Approval
Sep 26, 2024
Title
Plant-based diets and microbiome
Summary
The proposed study is a cross-sectional analysis that will examine the association between three plant-plant based diet indices, namely overall plant-based diet index (PDI), healthful (hPDI) and unhealthful (uPDI) versions and the oral microbiome using previously generated data by Emily Vogtmann in PLCO, NIH-AARP, and the Agricultural Health Study. All three of the plant-based diet indices limit animal foods, however the uPDI includes less whole grains, whole fruits, vegetables, nuts, legumes, vegetable oil, tea, and coffee while the hPDI includes greater nutrient dense plant-based foods such as whole grains, whole fruits, vegetables, nuts, legumes and vegetable oils but less refined grains, fried potatoes and chips, fruit juice, sugar sweetened beverages, sweets, and desserts (3,4). The overall PDI is similar to hPDI, however includes more refined grains, fried potatoes and chips, fruit juice, sugar sweetened beverages, sweets, and desserts. We hypothesize that all three PDI will be associated with different microbial characteristics.
Aims
The aim of this study is to:
1. Determine whether PDI, hPDI and uPDI are associated with oral microbiome in a cross-sectional analysis by pooling oral microbiome data across the NIH-AARP, PLCO, and Ag. Health cohorts measured by Emily Vogtmann in her case-cohort studies of lung, head-neck, stomach, esophageal, hepatobiliary, small intestine).
We hypothesize that PDI, hPDI, and uPDI will be associated with oral microbiome with PDI and hPDI having similar microbial characteristics and uPDI having different microbial characteristics. We will also examine associations between the PDI, hPDI, and uPDI components.
Collaborators
Emily Vogtmann, Christian Abnet, Sam Anyaso-Samual, Jinxian Shi, Douglas Monroe, Ting Zhang