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Etiologic heterogeneity across head and neck cancer subsites

Principal Investigator
Name
Anil Chaturvedi
Degrees
Ph.D.
Institution
National Cancer Institute
Position Title
Senior Investigator
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1652
Initial CDAS Request Approval
Aug 23, 2024
Title
Etiologic heterogeneity across head and neck cancer subsites
Summary
We will evaluate the etiologic heterogeneity across broad head and neck cancer sites (i.e., oral cavity, oropharynx, hypopharynx, and larynx), and within oral cavity (i.e., lip, oral tongue, gum, floor of mouth, and hard palate and other parts of the mouth) and oropharyngeal (i.e., base of tongue, tonsil, and soft palate and pharyngeal wall) subsites. With incidence of these head and neck cancer sites as the outcome, we will assess associations with various risk factors, including age, sex, race/ethnicity, BMI, education, smoking, alcohol use, as well as intake of specific types of vegetables based on botanical classifications.
Aims

- Evaluate etiologic heterogeneity across broad head and neck cancer sites, and within oral cavity and oropharyngeal subsites looking at associations with major risk factors, including smoking and alcohol intake.

- Evaluate associations with specific vegetable groups across broad head and neck cancer sites, and within oral cavity and oropharyngeal subsites, adjusting for known risk factors

Collaborators

Yukiko Yano, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Joseph E. Tota, Division of Cancer Epidemiology and Genetics, National Cancer Institute (current affiliation: Merck Inc., Rahway, NJ)
Barry I. Graubard, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Linda Liao, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Lisa Kahle, Information Management Systems Inc., Silver Spring, MD
Li. C. Cheung, Division of Cancer Epidemiology and Genetics, National Cancer Institute
Christian C. Abnet, Division of Cancer Epidemiology and Genetics, National Cancer Institute