Screening for Head and Neck Cancers within a high risk population

Principal Investigator

Name
Vinidh Paleri

Degrees
MS FRCS FRCSLT

Institution
The Royal Marsden Hospitals

Position Title
Professor of Head and Neck Surgery

Email
vinidh.paleri@rmh.nhs.uk

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-1640

Initial CDAS Request Approval
Aug 9, 2024

Title
Screening for Head and Neck Cancers within a high risk population

Summary
The problem:
Irrespective of the route of diagnosis, ~60% of HNC is diagnosed in stages III and IV

Aim:
To design a study that will screen for head and neck cancer within the population in England

Overarching Design:
A multi-stage implementation study where the earlier workpackages set the infrastructure and
the later workpackages deliver implementation and independent evaluation of a new approach
to identify early stage head and neck cancer (HNC) in high-risk, socio-economically deprived populations.

Aims

While the larger project aims to set in place a study to implement screening for HNC in a high risk population within England, the objective of this application to NCI is to identify the number and stage of HNCs identified in the PLCO cohort. We hope to identify data that may or may not, support our planned approach.

For reasons of intellectual property and confidentiality, we have not detailed our investigation plan.

Collaborators

1. The Royal Marsden NHS Foundation Trust, London
2. Health Innovation North East and North Cumbria,
3. UCL Partners (North London to the Essex coast)
4. Northern Cancer Alliance
5. RM Partners
6. The Institute of Cancer Research, London
7. City University of London
8. University of Leeds
9. Oracle Cancer Trust UK Limited
10. University College London
11. The Newcastle Upon Tyne Hospitals NHS Foundation Trust
12. St George's Hospital Foundation NHS Trust, London