Pan cancer deep learning model for predicting outcome of cancer
Principal Investigator
Name
Andreas Kleppe
Degrees
Ph.D.
Institution
Institute for Cancer Genetics and Infomatics, Oslo University Hospital
Position Title
Senior researcher
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCOI-1639
Initial CDAS Request Approval
Aug 15, 2024
Title
Pan cancer deep learning model for predicting outcome of cancer
Summary
In this project, we (Institute for Cancer Genetics and Informatics, Oslo University Hospital) intend to utilise deep learning to for prediction of patient outcome directly from scanned conventional haematoxylin and eosin (H&E) stained sections. We have successfully developed such a biomarker for patients resected for early-stage colorectal cancer and published our findings in The Lancet in 2020 (https://doi.org/10.1016/S0140-6736(19)32998-8). The marker was validated in an external cohort according to a pre-specified protocol and performed better than most other markers in terms of hazard ratios in stage-specific multivariable analyses. We now seek datasets to further validate our marker and to be able to develop a pan cancer marker and wish to gain access to The Prostate, Lung, Colorectal and Ovarian (PLCO) Pathology Images with associated data, in particular clinical, pathological and follow-up data. The ultimate aim of the project is to provide the clinic with an objective, automatic and low-cost tool that can enable clinicians and patients to make joint and more informed decisions on treatment options.
Aims
The ultimate aim of the project is to provide the clinic with an objective, automatic and low-cost tool that can enable clinicians and patients to make joint and more informed decisions on treatment options.
Collaborators
Andreas Kleppe (principal investigator), Tarjei S. Hveem, Hanne A. Askautrud, Wanja Kildal, Manohar Pradhan, Ole Johan Skrede, Anthony Manet, Audun Henriksen, Joakim Kalsnes. All at Institute for cancer genetics and infomatics, Oslo University Hospital, Oslo, Norway