An interdisciplinary approach to investigate factors influencing the changes in age-specific incidence of ovarian cancer.
Principal Investigator
Name
Imogen Rogers
Degrees
Ph.D
Institution
University of Sussex
Position Title
Research Fellow in Health Data Science
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1605
Initial CDAS Request Approval
Jul 8, 2024
Title
An interdisciplinary approach to investigate factors influencing the changes in age-specific incidence of ovarian cancer.
Summary
Studies have shown age-specific changes over time in the incidence of ovarian cancer. Since 2000 there has been a steady decline in the incidence among women aged 50+ years in England. Conversely, incidence rates have been gradually increasing among women aged <50y for the past 35 years. Other studies in America and Europe have observed birth cohort effects on changes in ovarian cancer incidence. We aim to utilise a number of individual and aggregated datasets, including the PCLO ovarian cancer dataset, to develop mathematical and statistical models to investigate the reasons behind these age-specific changes in incidence patterns. Potential factors of interest include reproductive history, use of hormonal contraceptives and hormone replacement therapy, increases in height/changing childhood growth patterns, smoking, the obesity epidemic and socioeconomic position.
Aims
Specific aims:
• To investigate the association between ovarian cancer risk and reproductive history, age at menopause and menarche, current and past measures of body size, use of hormonal contraceptives and HRT, smoking and measures of socioeconomic position within the PCLO data.
• To utilize this information in combination with data from other individual and aggregated datasets to develop mathematical and statistical models to investigate the factors driving the age-specific changes over time in ovarian cancer incidence.
Collaborators
Prof Anjum Memon, Brighton and Sussex Medical School.
Dr James van Yperen, University of Sussex
Dr Marianna Cerasuolo, University of Sussex
Dr Elizabeth Ford, University of Brighton