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Principal Investigator
Pingkun Yan
Rensselaer Polytechnic Institute
Position Title
Associate Professor
About this CDAS Project
PLCO (Learn more about this study)
Project ID
Initial CDAS Request Approval
Mar 25, 2024
Lung and Cardiovascular Disease Detection with Large Scale, Disease Screening Chest X-rays
Lung and heart diseases are the leading causes of death in the United States. Computerized lung and heart disease detection tools can detect nuanced imaging features related to lung and heart diseases to diagnose patients at high disease risk. Such predictive capability is key to devising effective health management strategies, enabling early intervention, and potentially saving lives by mitigating disease progession. This study aims to use the large scale lung cancer screening chest X-rays and detailed follow-up data in Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial to conduct thorough research investigating the viability of utilizing chest X-rays to develop computed-aid diagnosis models for lung and heart disease detection.

To develop advanced deep learning models that can build robust association between imaging information and the risk of diseases related to the lung and heart through the training on the large scale dataset made available by the lung cancer screening arm in Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.


Prof. Ge Wang, Fellow of IEEE, SPIE, OSA, AIMBE, AAPM, AAAS, and NAI; Professor, Biomedical Engineering Department, Rensselaer Polytechnic Institute
Dr. Mannudeep K. Kalra, Radiologist, Massachusetts General Hospital; Professor of Radiology, Harvard Medical School