Low carbohydrate dietary score and prostate, ovarian, and lung cancer incidence

Principal Investigator

Name
Maryam Farvid

Degrees
Ph.D

Institution
George Mason University

Position Title
Associate Professor

Email
mfarvid@gmu.edu

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-1501

Initial CDAS Request Approval
Mar 25, 2024

Title
Low carbohydrate dietary score and prostate, ovarian, and lung cancer incidence

Summary
A higher cancer incidence has been noted in individuals with type 2 diabetes. High circulating levels of insulin and insulin-like growth factor I (IGF-I) are believed to contribute to tumor growth and progression, increasing cancer risk. Various dietary factors influence these hormone levels, with carbohydrate intake being a major determinant of postprandial blood glucose and insulin levels. Additionally, protein and fat intake can affect the variations in circulating insulin and IGF-I levels. To comprehensively assess the impact of carbohydrate, protein, and fat intake on cancer development, we plan to evaluate the role of low-carbohydrate diet scores in the risk of prostate, lung, and ovarian cancer among participants in the PLCO study.

Aims

1- to evaluate the Associations of low carbohydrate diets including overall, animal-rich, and plant-rich low-carbohydrate diet scores with risk of prostate cancer
1- to evaluate the Associations of low carbohydrate diets including overall, animal-rich, and plant-rich low-carbohydrate diet scores with risk of ovarian cancer
1- to evaluate the Associations of low carbohydrate diets including overall, animal-rich, and plant-rich low-carbohydrate diet scores with risk of lung cancer

Collaborators

Nicholas Spence, University of Toronto
Master students at George Mason University