Skip to Main Content

An official website of the United States government

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

Principal Investigator
Name
Maryam Farvid
Degrees
Ph.D
Institution
George Mason University
Position Title
Associate Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1501
Initial CDAS Request Approval
Mar 25, 2024
Title
Low carbohydrate dietary score and prostate, ovarian, and lung cancer incidence
Summary
A higher cancer incidence has been noted in individuals with type 2 diabetes. High circulating levels of insulin and insulin-like growth factor I (IGF-I) are believed to contribute to tumor growth and progression, increasing cancer risk. Various dietary factors influence these hormone levels, with carbohydrate intake being a major determinant of postprandial blood glucose and insulin levels. Additionally, protein and fat intake can affect the variations in circulating insulin and IGF-I levels. To comprehensively assess the impact of carbohydrate, protein, and fat intake on cancer development, we plan to evaluate the role of low-carbohydrate diet scores in the risk of prostate, lung, and ovarian cancer among participants in the PLCO study.
Aims

1- to evaluate the Associations of low carbohydrate diets including overall, animal-rich, and plant-rich low-carbohydrate diet scores with risk of prostate cancer
1- to evaluate the Associations of low carbohydrate diets including overall, animal-rich, and plant-rich low-carbohydrate diet scores with risk of ovarian cancer
1- to evaluate the Associations of low carbohydrate diets including overall, animal-rich, and plant-rich low-carbohydrate diet scores with risk of lung cancer

Collaborators

Nicholas Spence, University of Toronto
Master students at George Mason University