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The relevance of co-morbidities and other modifiable risk factors beyond BMI in determining prognosis among gynecologic cancers

Principal Investigator
Name
Mauricio Cuello
Degrees
Md
Institution
Pontificia Universidad Católica de Chile
Position Title
Full Professor
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1457
Initial CDAS Request Approval
Apr 10, 2024
Title
The relevance of co-morbidities and other modifiable risk factors beyond BMI in determining prognosis among gynecologic cancers
Summary
The main focus of research of my group is to understand how co-morbidities and other modifiable risk factors can contribute on gynecologic cancer behavior either in the short or long rank in specific ethnicities. Currently, we are using different methodologies (statistics, AI such as machine learning) to characterize gynecologic cancers and identify main components affecting prognosis in these populations. We are collecting information from different public datasets to assess whether Latin-American or hispanic population behaves similarly or differently compared with caucasians, asiatics, or other ethnicities. We also want to investigate if specific populations are under represented in studies where conclusions maybe not applicable or available. PCLO cohorts contain information on several of our variables of interest.
Aims

To assess the effect of co-morbidities and other modifiable risk factor on oncologic outcomes among specific populations (ethnicities) included in different cohorts (e.g. TCGA, PCLO, so on)

To characterize body composition beyond BMI using imaging rendering and different image processing tools (in those cohorts where images our available) to better define visceral adiposity, lean mass, bone structure, and correlate such new definitions with co-existence of co-morbidities, age, physical activity.

To correlate age, BMI, body composition, physical activity over time with the prevalence of different co-morbidities, including gynecologic cancers.

Collaborators

Ignacio Wichmann, post-doc at School of Medicine Stanford University
Rene Bornar, Physicist and academic at the Institute of Medical Bioengineering at the Pontificia Universidad Catolica De Chile