Causal Estimators in Meta-analysis with Missing Data using PLCO's Lung Data

Principal Investigator

Name
Ruofan Bie

Degrees
Ph.D

Institution
Brown University

Position Title
Student

Email
ruofan_bie@brown.edu

About this CDAS Project

Study
PLCO (Learn more about this study)

Project ID
PLCO-1367

Initial CDAS Request Approval
Oct 30, 2023

Title
Causal Estimators in Meta-analysis with Missing Data using PLCO's Lung Data

Summary
In this project, we proposed causal estimators to transport estimation of causal average treatment effect from trials to target in meta-analysis, while handling two types of missing data. In this project, we define trials as an individual participant data meta-analysis that studies the same treatment effect; and we define target as a target sample that collects the same covariates as the trials but lack randomization information. We proposed g-formula estimator, IPW estimator and doubly-robust estimator to identify the causal average treatment effect in the target using trial data information. We provided analytical proof of the identification and large sample property of the proposed causal estimators and used simulation study to show the advantage of the proposed estimators over multiple-imputation estimators and pooled estimators. In the next step, we plan to use real-data analysis to further verify the feasibility and performance of our proposed estimator on real data. We plan to use the PLCO data as the trial and try to transport the estimation of causal average treatment effect on NLST data.

Aims

1. propose causal estimators for transportability in meta-analysis while handling two types of missing data (completed)
2. provide analytical proof of the identification and large sample property of the proposed estimators (completed)
3. run simulation study to compare proposed estimators with alternative methods (completed)
4. run real-data analysis to verify the feasibility of the proposed estimators (need PLCO data)

Collaborators

Jon Steingrimsson, Brown University