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Mitochondrial DNA Copy Number and Prostate Cancer Risk

Principal Investigator
Name
Sonja Berndt
Degrees
-
Institution
NCI, DCEG, OEEB
Position Title
-
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
2011-0037
Initial CDAS Request Approval
Mar 9, 2011
Title
Mitochondrial DNA Copy Number and Prostate Cancer Risk
Summary
Mitochondria have been implicated in the development of cancer due to their critical role in energy production and apoptosis. Recent studies have indicated that mitochondrial DNA copy number in peripheral blood may be associated with increased cancer risk; however, studies of prostate cancer have been small and retrospective making it unclear whether the association is the result of the disease process or truly an etiologic risk factor. Utilizing 700 cases and 700 controls from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we propose to evaluate the association between mitochondrial DNA copy number in the peripheral blood and prostate cancer risk. We anticipate that this study will expand our knowledge of the role of mitochondrial DNA in the etiology of prostate cancer.
Aims

The primary aims of the proposed study are: 1. To evaluate the association between mitochondrial DNA copy number in the peripheral blood and the risk of prostate cancer. Secondary aims of the proposed study are: 1. To examine the association between mitochondrial DNA copy number in the peripheral blood and prostate-specific antigen (PSA) levels. 2. To explore interactions between mitochondrial DNA copy number and select environmental factors that may influence oxidative stress and the risk of prostate cancer. 3. To explore the association between genetic variants in mitochondrial DNA and mitochondrial DNA copy number and potential effect modification on the risk of prostate cancer.

Collaborators

Laufey Amundadottir (DCEG)
Sarah Daugherty (DCEG)
Wen-Yi Huang (DCEG)
Qing Lan (DCEG)
Joshua Sampson (DCEG)

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