Comprehensive analyses of Fat Quality Index and incidence and mortality of lung cancer: A prospective cohort study
Principal Investigator
Name
Linglong Peng
Degrees
Ph.D.
Institution
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Position Title
Dr.
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1353
Initial CDAS Request Approval
Oct 10, 2023
Title
Comprehensive analyses of Fat Quality Index and incidence and mortality of lung cancer: A prospective cohort study
Summary
Fat quality index (FQI) has become a popular approach to assess dietary fat's effects on different health outcomes. For instance, previous research has explored the correlation between FQI and all-cause mortality(1), cardiovascular disease risk(2), and ovarian cancer patients survival(3). Crucially, to date, no studies have investigated the relationship between FQI and lung cancer incidence and mortality. Thus, given the aforementioned context, this study aims to explore the association between FQI and the incidence and mortality of total lung cancer and its different histological subtypes for the first time within the large, prospective Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial cohort.
Reference:
1. Santiago S, Zazpe I, Fernandez-Lazaro CI, de la O V, Bes-Rastrollo M, Martínez-González MÁ. Macronutrient Quality and All-Cause Mortality in the SUN Cohort. Nutrients (2021) 13:972. doi: 10.3390/nu13030972
2. Santiago S, Zazpe I, Gea A, Nuñez-Córdoba JM, Carlos S, Bes-Rastrollo M, Martínez-González MA. Fat Quality Index and Risk of Cardiovascular Disease in the Sun Project. J Nutr Health Aging (2018) 22:526–533. doi: 10.1007/s12603-018-1003-y
3. Zheng G, Gong T-T, Ma Q-P, Wei Y-F, Du Z-D, Zhao J-Q, Zou B-J, Yan S, Liu F-H, Sun M-L, et al. The association of macronutrient quality and its interactions with energy intake with survival among patients with ovarian cancer: results from a prospective cohort study. The American Journal of Clinical Nutrition (2023) 117:1362–1371. doi: 10.1016/j.ajcnut.2023.03.023
Reference:
1. Santiago S, Zazpe I, Fernandez-Lazaro CI, de la O V, Bes-Rastrollo M, Martínez-González MÁ. Macronutrient Quality and All-Cause Mortality in the SUN Cohort. Nutrients (2021) 13:972. doi: 10.3390/nu13030972
2. Santiago S, Zazpe I, Gea A, Nuñez-Córdoba JM, Carlos S, Bes-Rastrollo M, Martínez-González MA. Fat Quality Index and Risk of Cardiovascular Disease in the Sun Project. J Nutr Health Aging (2018) 22:526–533. doi: 10.1007/s12603-018-1003-y
3. Zheng G, Gong T-T, Ma Q-P, Wei Y-F, Du Z-D, Zhao J-Q, Zou B-J, Yan S, Liu F-H, Sun M-L, et al. The association of macronutrient quality and its interactions with energy intake with survival among patients with ovarian cancer: results from a prospective cohort study. The American Journal of Clinical Nutrition (2023) 117:1362–1371. doi: 10.1016/j.ajcnut.2023.03.023
Aims
Aims:
To investigate the prospective associations between FQI and incidence and mortality of lung cancer.
To explore the prospective associations between virous types of fats (including its different sources) and lung cancer outcomes among US population.
Collaborators
Yi Xiao 1, Haitao Gu 1, Zhiquan Xu 1, Yunhao Tang 1, Hongmei He 1, Yaxu Wang 1, Linglong Peng 1, Ling Xiang 2 et al.
1 Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
2 Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.