Impact of Caloric Restriction on Metabolomic Aging
Principal Investigator
Name
Waylon Hastings
Degrees
Ph.D.
Institution
The Administrators of Tulane Educational Fund
Position Title
Postdoctoral Researcher
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCO-1312
Initial CDAS Request Approval
Sep 5, 2023
Title
Impact of Caloric Restriction on Metabolomic Aging
Summary
Work in animal models, including non-human primates, has shown extensive evidence for increase in lifespan and healthspan following caloric restriction (CR) initiated in adulthood or midlife. The foremost data for the effects of CR in humans comes from the NIA-supported Comprehensive Assessment of the Long-term Effects of Reducing Energy (CALERIE™) trial. Using data from CALERIE™, researchers have provided evidence for significant improvements to cardiometabolic health, liver functioning, and immune health following moderate CR over a span of two years. Moreover, CR was shown to reduce the rate of biological aging estimated using epigenetic clocks and a panel of blood chemistry biomarkers.
The overarching goal of this proposal is to further explore the impact of CR on changes in metabolomic aging using two novel metabolomic age scores constructed in a reference population comprised of cohorts from the Consortium of Metabolomics Studies (COMETS).
The overarching goal of this proposal is to further explore the impact of CR on changes in metabolomic aging using two novel metabolomic age scores constructed in a reference population comprised of cohorts from the Consortium of Metabolomics Studies (COMETS).
Aims
Aim 1: Construct and implement metabolomic aging scores in COMETS cohorts to describe the distribution of metabolomic aging scores across sociodemographic strata
Aim 2: Implement metabolomic aging scores in CALERIE™ to test if CR reduces the rate of metabolomic aging
Aim 3: Investigate functional significance of metabolites in metabolomic age scores
Collaborators
Dr. Steven C. Moore, Ph.D., M.P.H., Metabolic Epidemiology Branch, National Cancer Institute