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The influence of ovarian cancer treatment and treatment related complications on patients’ overall survival

Principal Investigator
Name
Kaja Michalczyk
Degrees
M.D.
Institution
Pomeranian Medical University
Position Title
Resident Doctor, Department of Gynecological Surgery and Gynecological Oncology
Email
About this CDAS Project
Study
PLCO (Learn more about this study)
Project ID
PLCO-1187
Initial CDAS Request Approval
Mar 29, 2023
Title
The influence of ovarian cancer treatment and treatment related complications on patients’ overall survival
Summary
Ovarian cancer remains the leading cause of death among gynecological cancers. Early cancer diagnosis allows for a better patient prognosis. However, due to its asymptomatic progression and limited screening methods, most patients are diagnosed in advanced stages when the disease has already metastasized. Epithelial ovarian cancer accounts for approximately 90% of ovarian cancers. Its treatment consists of radical surgery and either adjuvant or neoadjuvant chemotherapy. However, due to chemoresistance and high recurrence, the 5-year patient survival rates remain at approximately 35-50% (Torre et al. 2018). The advanced metastatic disease remains the greatest challenge in ovarian cancer treatment. Compared to primary tumors, metastatic tumors share a wide spectrum of mutations and are chemotherapy-resistant (Vang et al. 2013; Shah et al. 2009; Paris et al. 2006).

Current surgical ovarian cancer treatment aims in complete cytoreduction – sometimes involving complete resection of the ovarian tumor, reproductive organs, omentum, and sometimes sigmoid colon, yet in some patients, the total excision of the lesions is not possible.
The scope of the treatment can cause fear and anxiety among patients as well as require specific preparations including medical imaging (CT, MRI) medical consultations, dietary preparations, psychologists, etc. that can result in treatment delays. As the surgical treatment is very complex, it carries multiple treatment related risks of complications that may affect patient treatment and overall survival. In this study we would like to concentrate on the analysis of surgical treatment of ovarian cancer patients in the dataset and complications that occurred during the cancer treatment.
Aims

- The analysis of the scope of the surgery (radical treatment/ non radical) and procedures performed during the surgery (BSO, USO, hysterectomy, bowel resection, omentectomy, lymphadenectomy, tumor debulking)
- the type of cancer (ovarian, peritoneal, fallopian tube) and the possibility of primary debulking surgery vs interval debulking surgical treatment
- To analyze patients' survival depending on the type of surgery (IDS, PDS) and treatment
- Analyze the complications that occurred during ovarian cancer treatment and their correlation with the scope of surgery performed as a part of surgical treatment. To evaluate for differences between complications in the PDS and IDS group
- Evaluate on the influence of patients characteristics (age, race, comorbidities, hypertention, heart attack, stroke, emphysema, bronchitis, diabetes, arthritis, osteoporosis, diverticulitis, gallbladder surgery, ciggarets use, BMI, weight, colon and liver comorbidities or any previous history of cancer, use of aspirin) on the type of surgery, complications that occurred and patients survival
- To analyze if patients' previous medical history influence the radicalness of surgery and its type (IDS/ PDS) – miscarriages, tubal ligation, ovarian cysts, endometriosis, uterine fibroids), amount of pregnancies, hysterectomy in the past

Collaborators

Anita Chudecka-Głaz, Associate Professor, Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland

Janusz Menkiszak, Associate Professor, Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland