Pan-cancer genome-wide association study of tissue disruption phenotypes on standard histologic images from PLCO
Principal Investigator
Name
Mustapha Abubakar
Degrees
M.D., Ph.D.
Institution
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, USA
Position Title
Stadtman Investigator
Email
About this CDAS Project
Study
PLCO
(Learn more about this study)
Project ID
PLCOI-1172
Initial CDAS Request Approval
Mar 8, 2023
Title
Pan-cancer genome-wide association study of tissue disruption phenotypes on standard histologic images from PLCO
Summary
Disruption of organ-specific tissue ecosystems is a hallmark of malignant transformation, tumor progression, and clinical outcomes, particularly for solid cancers. Germline genetic variants in susceptibility genes have been shown to be associated with specific pathological characteristics of tumors from several sites. However, it is not known whether germline genetic susceptibility variants confer vulnerability to, and/or impact the pattern and degree of, tissue ecosystem disruption in tumors. Here, we aim to characterize the relationships between germline genetic variation and organ-specific tissue ecosystem disruption phenotypes across several cancer sites in the Prostate, Lung, Colorectal, and Ovarian cancer (PLCO) screening trial.
Aims
i. Characterize tissue ecosystem disruption phenotypes in tumor tissues using computational pathology of standard histologic images
ii. Conduct a genome wide association study (GWAS) to test associations between germline genetic variants and distinct tissue disruption phenotypes in several cancers.
Collaborators
- Maire Duggan (Integrative Tumor Epidemiology Branch (ITEB) collaborating pathologist/DCEG, NCI)
- Scott Lawrence (Molecular and Digital Pathology Laboratory (MDPL), CGR)
- Karun Mutreja (MDPL, CGR)
- Aaron Rozeboom (MDPL, CGR)
- Jianxin Shi (Biostatistics Branch, DCEG)
- Wendy Wong (Office of the Director, DCEG)
- Huang Wen-Yi (Metabolic Epidemiology Branch (MEB), DCEG)
- Neal Friedman (MEB, DCEG)
- Mitch Machiela (ITEB, DCEG)